ABSTRACT
The effect of tiaprofenic acid [10 mg/kg] or naproxen [10 mg/kg] alone and each in combination with insulin [0.2 IU/kg] or glipizide [15 mg/kg] on serum glucose, bilirubin, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] was investigated before one and two weeks after treatment in alloxan-diabetic rats. The present study showed that tiaprofenic acid, naproxen, insulin, glipizide and their combinations caused a decrease in blood glucose level in the diabetic rats. Insulin, glipizide and naproxen-glipizide combination significantly reduced serum bilirubin level. Tiaprofenic acid and its combination with glipizide significantly elevated serum bilirubin level. Insulin, naproxen or tiaprofenic acid combination with either insulin or glipizide did not alter serum AST level. But glipizide significantly reduced, while tiaprofenic acid significantly elevated serum AST level after the second week of treatment. Insulin, naproxen, glipizide or their combinations did not change serum ALT level. Tiaprofenic acid significantly elevated serum ALT level after two weeks. In conclusion, both naproxen and tiaprofenic acid have hypoglycemic effect in diabetic rats and naproxen potentiated the action of insulin on blood glucose. Caution must be taken when using each of them in diabetics on insulin therapy and dose adjustment may be necessary to obtain the best results. Tiaprofenic acid causes a significant hepatic disturbance shown by elevated bilirubin, AST and ALT levels in diabetic rats. Human studies may be required to confirm these Findings