Nephro-toxic study of endosulfan

Two groups of mature rats [30 rats each] were daily dosed orally with 5 or 10 mg/kg b. wt. endosulfan pesticide for 15 successive days. Serum samples were collected after the 5th, 10th and 15th doses. Kidney function tests were adopted on the collected samples. The results were compared with control group [15 rats]. The electrolytes [sodium, potassium and calcium] and total protein in the serum of treated rats showed marked decrease specially in that group dosed with 10 mg/kg b. wt. Serum urea, blood urea nitrogen, creatinine and serum alkaline phosphatase measured showed marked increase in the both treated groups. The illustrated results indicated that endosulfan pesticide has nephrotoxic effect on experimentally intoxicated rats

Histopathological studies on rats injected with repeated doses of scorpion venom

Two groups of adult white male rats [20 animals each] were injected daily for six weeks i.m. with 1/10 or 1/20 LD[50] scorpion venom respectively, while third group of 10 rats were kept as control. At the end of the experiment, all the animals were sacrificed and P.M. lesions were recorded. On the other hand autopsies from: skeletal muscles, liver, kidneys, lungs, spleen, testicles, brain and spinal cord were prepared for histopathological study. The microscopical findings were described and illustrated