Infection in immune-deficiency states: aplastic anemia and leukemia a two-year review of cases at the UP-PGH Medical Center, (1974-1975)

In this two-year review of 107 cases of Aplastic Anemia, and Acute and Chronic Leukemia, it was found that the focus of infection in over one half of the total number of cases, was pulmonary, with soft tissue and urinary tract infection ranking second and third. The Onset of infection was found to be approximately 15 days after admission in aplastics, and 12 days for leukemicsStaphylococcus Aureaus was the most common pathogen in community acquired infections, while Pseudomonas, Klebsiella and E. Coli were common among the hospital acquired group. More deaths were associated with gram-negative organisms and, at a mean neutrophile count of 1,450/cu.mm. However, no significant relationship could be established between death and lymphocyte levelIn leukemia, markedly low neutrophile counts were observed at the time infection was known to set in, while no change was observed in the aplastic group, from admission to time of infection. It was only with the chronic leukemics that a significant decrease in lymphocyte count was noted. (Summary)

Open heart operations using disposable plastic oxygenators, 5% dextrose in distilled water prime, normothermia, and a sigmamotor pump (T-M2)

Open heart operations were successfully performed on six consecutive patients at the Philippine General Hospital. Total cardiopulmonary bypass was accomplished using disposable plastic oxygenators, five percent dextrose in distilled water prime, normothermia and a single sigmamotor pump (T-M2). The technic of perusion, clinical material, physiologic data gathered and the financial costs of these operations were discussed. All the patients survived their operations. No complication could be attributable to the method of cardiopulmonary bypass employed. The technic of cardiopulmonary bypass described appears practical, safe, and relatively inexpensive. This method of bypass has been adopted for use by the Department of Surgery for all types of open heart operations. (Author)

The pulmonary circulation some aspects of normal and disturb function

This presentation dealt with some aspects of the physiology and pathophysiology of the pulmonary circulation, in particular, differences between the pulmonary and systemic circuits, regulation of pulmonary blood flow, pressure-flow relationships, ventilation-perfusion ratio and pulmonary hypertensionSome emphasis was put on regulation of pulmonary blood flow, since it is felt that this aspect of pulmonary physiology is an interesting field for further studySome procedures used in evaluating the status of the pulmonary circulation were mentionedAs regards pulmonary hypertension, the value of cardiac catheterization in its differential diagnosis and prognosis was discussed, and stress laid on the advisability of differentiating the "primary" from the secondary form, as well as on the value of determining "reversibility."While covering many topics, this discussion has undoubtedly, barely scratched the surface. (Summary)