Linfomas asociados a infección por Virus de Inmunodeficiencia Humana: Experiencia de un centro hospitalario de la V región, Chile / Lymphomas associated with human immunodeficiency virus infection: Retrospective review of medical records

Background: The incidence oflymphoma increases enormously inpatients infecten with the human immunodeficiency virus (HIV). Aim: To describe the incidence, clinical and histológica! characteristics, treatments and survival of lymphomas associated with HTV infection. Material and Methods: Retrospective review of medical records ofpatients with HIV and lymphoma, treated in a public hospital, between January 2001 and June 2009. Results: Twenty-two mole patients were included but 14 had immunohistochemical confirmation ofthe lymphoma. The accumulated incidence for thisperiod was 2.8 percent. The median age at lymphoma diagnosis was 39.5 years. Twelvepatients (86 percent) had non-Hodgkin lymphoma (NHI) and two (14 percent) Hodgkin lymphoma. The main pathological type of non-Hodgkin lymphomas was diffuse large B cell in seven cases (50 percent). The mean CD4 cell count and viral load were 83 cell/mm³ (33.5-113.5) and 26.000 RNA copies/ml (1210-196500), respectively Twelve patients (86 percent) had B type symptoms of lymphoma at the moment of diagnosis. Eleven patients (29 percent) received chemotherapy with or without radiotherapy, onepatient (7 percent) received radiotherapy alone and two patients (14 percent) received palliative symptomatic treatment. Six cases (43 percent) received highly active antiretroviral therapy simultaneously with chemotherapy. Global mortality in this series was 57 percent (8patients) with a median survival time of 5.8 months (2.6-26.2). Conclusions: In this series ofpatients infected with HIV, a predominance of aggressive histológica! subtypes of lymphomas and low complete remission rates, were observed.

Fractura en hueso patológico como factor pronóstico de sobrevida en mieloma múltiple de alta masa celular / Pathological fracture as a prognostic factor of survival in multiple myeloma of high celular mass

El mieloma múltiple es una neoplasia de las células plasmáticas que ha permanecido incurable y que tiene como complicaciones la destrucción ósea, la falla renal, la hipercalcemia y la hiperuricemia. El objetivo principal del trabajo fue establecer un factor pronóstico de sobrevida de acuerdo al perfil temporal de presentación de la fractura en hueso patológico. De un total de 96 casos, se revisaron retrospectivamente 79 pacientes diagnosticados como mieloma múltiple de alta masa celular en el Hospital Dr. Gustavo Fricke, entre enero del 1996 y septiembre del 2005. Se encontró una sobrevida promedio de 25 meses y una distribución de la patología según el sexo de 1:1. Sin embargo, los hombres tuvieron la mitad de sobrevida que las mujeres. Así también se encontró que un tercio de los pacientes presentó la fractura o falta renal como debut del mieloma, teniendo una sobrevida significativamente menor.