ABSTRACT
This study was undertaken to evaluate the effectiveness of garlic and panax as dietary additions in alleviating the toxicity of aflatoxin B1 [AFB1] in male Chinchilla rabbits. Thirty rabbits [12-14 weeks age and mean body weight 1589 +/- 5.079 gm. Were classified into nearly 6 similar groups in their average body weights: first and second groups served as positive and negative controls, third and fourth groups received Aflatoxin B1 [AFB1] plus rather garlic or panax ginseng respectively. Fifth and sixth groups received only garlic and panax ginseng respectively. Rabbits were orally administered their respective doses of [AFB1] every other day for 10 weeks. The hemato-biochemical parameters and enzymatic activies were evaluated. Results showed that AFB1 significantly [P<0.05] decreased hemoglobin [Hb] total erythrocytic count [TEC] and [PCV]. Garlic and panax ginseng caused an increase in these parameters and counteracted the negative effect of AFB1 in the treated groups. Additionally, serum concentrations of total protein, albumin and glucose were significantly [P<0.05] declined by treatment with aflatoxin B1. Garlic and panax ginseng caused non significant increases in these parameters and lessen the harmful effect of AFB1. On the other hand, aflatoxin treatment caused significant increases [P<0.05] in the activities of serum asparatate aminotransferase [AST], alanine aminotransferase [ALT] and alkaline phosphatase [ALP] in the treated groups also caused significant increases [p<0.05] in cholesterol and total bilirulin. Garlic and panax ginseng caused significant decreases in these parameters and alleviated the harmful effects of AFB1. Whereas total leukocyte count [TLC], urea and creatinine were not significantly affected by aflatoxin treatment. Generally, it is interesting feature that the dietary additions of macerate garlic or panax ginseng alone in G5 and G6 respectively had no negative effects on most of the previous parameters. Also the presence of garlic or panax ginseng could diminished the adverse effects of AFB1 on most of hematological and biochemical values and enzymatic activities in rabbits