ABSTRACT
Objectives: Comparison of effects of propofol and isosorbide dinitrate during rewarming on cardiopulmonary bypass in patients undergoing coronary artery bypasses grafting
Methods: it was randomized prospective clinical trial. One hundred and twenty patient [120] undergoing CABG surgery were included in this study. Group-1 [Study group, n=60]: in which only propofol infusion used during rewarming and Group-ll [control Group, n=60] in which isosorbide dinitrate and propofol infusion combination was used during rewarming. The data was entered and analyzed through SPSS Version 19
Independent sample T-test and chi-square test were used for data analysis. P value of < 0.05 was taken as significant
Results: Mean arterial pressures during rewarming were 63.41 +/- 3.61 mmHg in propofol group versus 60.80 +/- 4.86 mmHg in control group [p-value 0.001]. Core temperature on weaning from cardiopulmonary bypass was 37.11 +/- 0.49 °C in propofol group and 37.00 +/- 0.18 °C in control group. After drop in core temperature was little more in propofol group [1.02 +/- 0.36 °C] versus 0.96 +/- 0.37 °C in control group but this difference was not statistically significant [p-value 0.41]. Mean Ventilation time after surgery in propofol group was 4.65 +/- 0.65 hours versus 5.03 +/- 0.81 hours in control group [p-value 0.006]
Conclusion: Propofol alone is capable of fulfilling the requirements of adequate rewarming during Cardiopulmonary bypass and can produce more hemodynamic stability and early post-operative recovery