ABSTRACT
Abstract Oxazolidine derivatives (OxD) have been described as third-line antibiotics and antitumoral agents. The inclusion complexes based on cyclodextrin could improve the solubility and bioavailability of these compounds. A novel synthetic OxD was used, and its inclusion complexes were based on 2-hydroxy-beta-cyclodextrin (2-HPßCD). We conducted an in silico study to evaluate the interaction capacity between OxD and 2-HPßCD. Characterization studies were performed through scanning electron microscopy (SEM), Fourier-transformed infrared (FTIR), nuclear magnetic resonance spectroscopy (1H-NMR), X-ray diffraction (XRD), and thermal analyses. A kinetic study of the OxD was performed, including a cytotoxicity assay using peripheral blood mononuclear cells (PBMCs). The maximum increment of solubility was obtained at 70 mM OxD using 400 mM 2-HPßCD. SEM analyses and FTIR spectra indicated the formation of inclusion complexes. 1H-NMR presented chemical shifts that indicated 1:1 stoichiometry. Different thermal behaviors were obtained. The pharmacokinetic profile showed a short release time. Pure OxD and its inclusion complex did not exhibit cytotoxicity in PBMCs. In silico studies provided a foremost insight into the interactions between OxD and 2-HPßCD, including a higher solubility in water and an average releasing profile without toxicity in normal cells
Subject(s)
Solubility/drug effects , Cyclodextrins/agonists , Microscopy, Electron, Scanning/methods , Magnetic Resonance Spectroscopy/methods , Spectroscopy, Fourier Transform Infrared/methods , Proton Magnetic Resonance Spectroscopy/methods , Anti-Bacterial Agents/analysisABSTRACT
O plasma rico em plaquetas ganhou notoriedade nas últimas décadas pela possibilidade de acelerar o processo de cicatrização. Este artigo tem como objetivo fornecer informações sobre o tema e revisar estudos sobre seu uso na ortopedia.
Subject(s)
Guided Tissue Regeneration , Orthopedics , Platelet-Rich Plasma , Sports MedicineABSTRACT
Os autores fazem revisão bibliográfica sobre fraturas do quadril, com foco nas fraturas mais prevalentes na população idosa, com o objetivo de difundir o conhecimento para o médico generalista das principais manifestações clínicas, etiopatogenia, diagnóstico e respectivos tratamentos destas patologias tão freqüentes na prática médica.
Subject(s)
Hip Fractures/classification , Hip Fractures/diagnosisABSTRACT
Este artigo tem como objetivo apresentar um estudo das causas mais comuns de dor no joelho em pacientes adultos e propor uma adequada avaliação por parte do clínico, visando identificar as patologias mais freqüentes desta região.