ABSTRACT
Objectives: The aim of this study is to evaluate some biochemical parameters including serum creatine phosphokinase [CPK] and lactate dehydrogenase [LDH] in newborns with birth asphyxia
Methods: This retrospective study was conducted in King Hussein medical center over two year period. Fifty seven patients were enrolled in this study who fulfills the inclusion criteria [group A], another sixty patients were enrolled as control [group B]. Biochemical parameters as CPK and LDH were measured in both groups
Results: Forty seven patients out of fifty [82%] showed liver involvement indicated by the elevation of LDH and CPK, done in the first three days of life. Most of the patients were in the grade one of HIE according to sarnat and sarnat classification. Statistical analysis was done for the available data and showed significant elevation of both CPK and LDH in asphyxiated babies
Conclusion: Measurement of both CPK and LDH in babies with high risk and who are suspected to have birth asphyxia, can help in predicting those who are candidate for neuroprotective measures as hypothermia, which might lead to significant improvement in neurodevelopment abilities of neonate later on
ABSTRACT
Sacral agenesis, known also as caudal regression syndrome, is a rare congenital abnormality characterized by absence of a variable amount of sacrum, lumbar spine and associated neural elements. It is mostly seen in infants of diabetic mothers. Nearly all patients have genitourinary anomalies, neurogenic bladder being the most common. Other associated anomalies include cardiac, gastrointestinal and orthopedic. Here, we present a rare type of lumbosacral agenesis in an infant of a diabetic mother. It was diagnosed antenatally at 26 weeks of gestation
ABSTRACT
To show that intravenous immunoglobulin is safe and effective alternative treatment in newborn with iso-immune hemolytic jaundice. This study was carried out in neonatal unit in King Hussein Medical Center [KHMC] and Queen Alia Hospital during two years period of all cases who presented with jaundice either RH or ABO iso-immune jaundice in the first day of life. All patients received phototherapy and intravenous immunoglobulin. There were 91 patients with iso-immune jaundice admitted to the neonatal unit in their first day of life. Eighty five patients out of 91 [93.4%] were due to ABO incompatibility. Six patients out of 91 [6.6%] were due to RH incompatibility. Direct coombs test was positive in all cases of RH incompatibility and in 16 cases of ABO incompatibility. Intravenous immunoglobulin [0.5g/kg] was given to all patients over four hours every 24 hours for three doses. Exchange transfusion was done for one patient only [1%]. Blood transfusion was given for 22 patients out of 91 [24%]. Hospital stay was around 3-4 days in majority of cases. Intravenous immunoglobulin in newborn with ABO or RH hemolytic jaundice is effective in reducing hemolysis, serum bilirubin level and the need for exchange transfusion