Pre-pregnancy obesity and the risk of peripartum cardiomyopathy: A systematic review and meta-analysis

The outcome of this review is to assess the association between pre-pregnancy obesity and PPCM incidence. There were a total of 5.373.581 participants were included in this study. Pre-pregnancy obesity was significantly associated with PPCM incidence compared to normal-weight subjects (OR ¼ 1.79 (1.16,2.76); p ¼ 0.008; I 2 ¼ 59%, Pheterogeneity ¼ 0.04). The sub-group analysis showed that pre-pregnancy women with obesity class I (OR ¼ 1.58 (1.20,2.07); p ¼ 0.001; I 2 ¼ 0%, Pheterogeneity ¼ 0.64) and class II and III (OR ¼ 2.65 (2.04,3.45); p < 0.001; I 2 ¼ 6%, Pheterogeneity ¼ 0.36) was significantly associated with PPCM incidence compared to normal-weight subjects.