ABSTRACT
Measurement of CEA, CA19-9, and A-FP are tumor markers for colorectal carcinoma, to be used for follow up and to detect early relapse. Specialized Surgical Baghdad -Teaching Hospital. To shade a light on the sensitivity and specificity of these tumor markers [CEA, CA 19-9, and a IT] for colorectal carcinoma. A total of 30 patients with colorectal cancer were studied between June 2003 and April 2004, only 25 were followed up because the remaining 5 were beyond treatment as their CKA level was above 60 ng/ml. so they were excluded. The other patients were studied pie and 3 months post operative!]' as well 20 other non malignant G.I patients and 30 healthy controls. The serum was estimated for CBA, CA19-9, and A-FP by RLFA [Enzyme Linked fluorescent Assay] method. The results show that there is significant difference between scrum level of CCA in pie- operative colorectal cancer patients and control [P<0.0005], and significant difference between the same patients and the post operative group [P<0.05]. While Tor the determination of serum CA 19-9 there arc insignificant differences between the pre- operative group and control, and between the pre- and post- operative groups [P>0.05]. As for the results for a FP There is significant difference between the pre-operative group patients and the non malignant Ci.I patients [P <0.05], and significant difference between the pre- and post- operative groups [P< 0.1]. Significant differences were found in the result of tumor markers [1 A, and a FP studied in patients with colorectal cancer as compared with the other non malignant [I. I patients and control, these results confirm that these markers are good predictors for colorectal cancer. While for CA 19-9 can only be useful in metastasis GIT carcinomas. The sensitivity of using the above mentioned tumor markers together is 84%, while the specificity is 66%