ABSTRACT
The present study was designed to investigate the in alloxan (120 mg/kg b.wt) induced diabetic rats. The ethanolic extract of the whole plant of Mollugo nudicaulis (200mg/kg) administered orally to the diabetic rats for 21 days, produced significant decrease in the level of blood glucose, cholesterol, triglycerides, low density lipoprotein (LDL), lipid peroxidation, liver glycogen, serum creatinine, urea, uric acid and liver marker enzymes such as AST, ALT, ALP. It also produced significant increase in High density lipoprotein (HDL), Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Glutathione-S-Transferase (GST), Reduced glutathione (GSH), Vitamin C, which clearly show the antioxidant property of extract. The effect of the ethanolic the extract of Mollugo nudicaulis was compared with the standard drug Glibenclamide (1.25mg/kg b.wt).