ABSTRACT
The effect of nutrition in the course of multiple sclerosis [MS] is a topic of great interest. The present study was aimed to evaluate the immunoglobin E [IgE] against egg and fish in MS patients compared to healthy controls. Between March 2012 and July 2012, 48 MS patients were selected and compared with 48 healthy subjects to assess the frequency of IgE against egg and fish in MS patients compared to healthy control. Fish and Egg specific IgE was determined by Immuno CAP. Sex and the frequency of specific IgE were compared between study groups by Chi-square test. Total of 96 subjects was assessed [22% male and 78% female]. The mean age of the study subjects was 30.8 +/- 6.6 years. Mean age of case and control groups was 30.7 [ +/- 6.9] versus 30.9 +/- 6.3, respectively [P = 0.83]. There were no detection of egg and fish specific IgE in serum of MS patients and healthy subjects. IgE allergy against fish and egg may be very unlikely to affect MS course
Subject(s)
Humans , Female , Male , Immunoglobulin E , Fishes/immunology , Eggs , Food HypersensitivityABSTRACT
Toluene diisocyanate [TDI] is an imperative chemical substance used in the production of polyurethane foams, elastomers, paints and coatings that cause a variety of health problems in workers who are exposed in work places. This study aimed to determine the asthma symptoms and serum specific IgE levels in TDI exposed workers and comparing the results with healthy control group. All the plants that use TDI in the manufacturing of paint and glue in the west of Tehran Province entered to the study and all the workers [550] completed modified initial questionnaire of the NIOSH, the questions were consisted of asthma symptoms. For each symptomatic exposed worker one healthy, sex and age matched control selected. Total IgE and Specific TDI IgE tests were done for each case and control groups. Among 550 TDI exposed workers, 26[4.7%] had asthma symptoms. Nine [34.6%] of symptomatic workers who were exposed to TDI were active cigarette consumer versus 3[11.5%] unexposed workers, P=0.049[CI= 0.953-17.29] OR=4.059. Nine [34.6%] workers had positive family history of atopy versus 1[3.8%] unexposed workers, P=0.0138 [CI= 1.45-305.41] OR=13.24. TDI specific IgE was found in 2 TDI exposed workers and 1 unexposed worker [P=0.5]. Mean of total IgE was 339.05 in exposed workers [P=0.201]. This study provides clinical and paraclinical data of workers exposed to TDI and points to a relation between atopy and smoking habit with asthma symptoms that offer preventing recommendations for TDI exposed workers and their heath administrators
ABSTRACT
Immunophenotyping of lymphocytes is very essential for evaluation of immune system. Due to the effect of environmental factors and ethnical diversity on immune system, establishment of an internal normal range of lymphocyte subsets is a necessity for each population. The aim of this study was to determine the normal range of T and B lymphocytes, and NK cells in normal Iranian adults. Two hundred and thirty three Iranian normal adult volunteers took part in this study. Complete Blood Count [CBC] was performed for them with Sysmex [KX21] and cells with CD3, CD4, CD8, CD19 and CD16/56 surface markers were simultaneously detected by flow cytometry method with FACstar system. Their percentile and absolute count were determined. The volunteers were 150 male and 83 female. Mean percentages of lymphocyte subpopulation were: CD3 [67.66 +/- 7.76], CD19 [14.41 +/- 5.09], CD4 [39.22 +/- 6.7], CD8 [25.42 +/- 5.4] and CD16/56 [10.14 +/- 6.42]. Also, their mean absolute count of lymphocyte bearing. CD3, CD19, CD4 and CD8 were l,504 +/- 505/microl, 332 +/- 186/microl, 827 +/- 313/microl and 522 +/- 185/microl, respectively. Our results are comparable with similar Asian results from other Asian population, but are different from European population, we therefore conclude that it is necessary for each laboratory to establish an internal normal range for the lymphocytes bearing above-mentioned markers