ABSTRACT
Background: Perinatal asphyxia is amongst the common problem of neonates and there exists a significant contribution to the neonatal morbidity and mortality. It is observed as a common and a vital cause of the preventable cerebral injury. The prediction of the perinatal asphyxial outcome is very important but dreadful. There is a limited role for APGAR score to predict the immediate outcome, like HIE and the long-term neurological sequelae observational error may happen in APGAR. But the biochemical parameters can truly be relied upon. This study was done to assess urinary uric acid/urinary creatinine ratio (UA/Cr) as a non-invasive marker for perinatal asphyxia and co-relate its absolute value to the degree of the perinatal asphyxia.Methods: In this prospective case control study conducted in the Pediatrics Department of Shri Ram Murti Smarak Institute of Medical Sciences between Nov 2017 to May 2019, 42 asphyxiated and 42 non-asphyxiated newborns were included. Detailed history and assessment were for all the enrolled newborns. Spot urine samples were sent for the uric acid and creatinine estimation. Results were documented, and statistical analysis was performed.Results: Urinary uric acid to creatinine ratio used as additional non-invasive, early and easy biochemical marker of the birth asphyxia that biochemically supports severity grading and clinical diagnosis of the asphyxia by APGAR score.Conclusions: The ratio of the urinary uric acid and creatinine enables rapid and early recognition of asphyxial injury and also the evaluation of its severity and potential for short-term morbidity or death.
ABSTRACT
Introduction: Suicide ideation is common amongst peoplewith HIV/AIDS but may not often indicate any significantrisk of suicide. However, persistent suicide ideation withassociated depression, could be serious and must beinvestigated promptly and carefully. This communicationaims at examining prevalence of suicide ideation in depressedPeople Living with HIV/AIDs (PLHAs) and in relation tosome of its socio-demographic and clinical variates.Material and Methods: This is a part of a cross sectionalstudy on depression in 104 HIV/AIDS patients, registered atART Clinic of a teaching hospital, undertaken in 2013-14 atJhansi in Uttar Pradesh (India). On applying GHQ tool, 70patients of depression were identified. These 70 patients werefurther studied for suicide ideation.Results: The prevalence of suicide ideation among depressedHIV/AIDS was found 60% as well as significant associationof suicide ideation was found with occupation, habitat and permonth income of depressed HIV/AIDS patients.Conclusions: The significant association between sociodemographic profile of depressed HIV/AIDS patients andsuicide ideation is an important marker that should alertclinicians to underlying suicidal risk. Clinicians shouldroutinely enquire on suicidality in depressed PLHAs andassist them in their early diagnosis and intervention.