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Arq. neuropsiquiatr ; 74(9): 723-729, Sept. 2016. graf
Article in English | LILACS | ID: lil-796042

ABSTRACT

ABSTRACT The purpose of the present study was to investigate the effect of crocin on brain oxidative damage and memory deficits in a 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease. Male Wistar rats were subjected to unilateral injection of 6-OHDA (16 µg) into the medial forebrain bundle and treated with crocin (30 and 60 mg/kg) for six weeks. The rats were tested for memory performance at six weeks after 6-OHDA infusion, and then were killed for the estimation of biochemical parameters. The increase in thiobarbituric acid reactive substances (TBARS) and nitrite levels in the hippocampus were observed in the 6-OHDA lesioned rats, which was accompanied by memory deficits in a passive avoidance test at the end of week 6. Moreover, treatment with crocin decreased TBARS and nitrite levels in the hippocampus, and improved aversive memory. The present study conclusively demonstrated that crocin acts as an antioxidant and anti-inflammatory agent in the hippocampus of parkinsonian rats and could improve aversive memory through its properties.


RESUMO O objetivo do presente estudo foi investigar o efeito da crocina no dano oxidativo cerebral e nos déficits de memória em um modelo 6-OHDA de doença de Parkinson. Ratos Wistar machos foram submetidos à injeção unilateral de 6-OHDA (16 μg) em MFB e tratados com crocina (30 e 60 mg/kg), durante 6 semanas. Os ratos foram testados quanto ao desempenho da memória 6 semanas após a infusão de 6-OHDA, e, em seguida, foram sacrificados para a estimativa dos parâmetros bioquímicos. O aumento nos níveis de TBARS e de nitrito no hipocampo foram observados em ratos 6-OHDA lesionados, acompanhado por déficits de memória em um teste de esquiva passiva no final da semana 6. Além disso, o tratamento com crocina diminuiu os níveis de nitrito e de TBARS no hipocampo e melhorou a memória aversiva. O presente estudo demonstrou conclusivamente que a crocina age como um antioxidante e um agente anti-inflamatório no hipocampo de ratos parkinsonianos e pode melhorar a memória aversiva através de suas propriedades.


Subject(s)
Animals , Male , Parkinson Disease/drug therapy , Carotenoids/pharmacology , Cerebral Cortex/drug effects , Oxidative Stress/drug effects , Memory Disorders/prevention & control , Antioxidants/pharmacology , Parkinson Disease/physiopathology , Parkinson Disease/metabolism , Sulfhydryl Compounds/analysis , Lipid Peroxidation/drug effects , Random Allocation , Cerebral Cortex/physiopathology , Cerebral Cortex/metabolism , Oxidopamine , Thiobarbituric Acid Reactive Substances/analysis , Rats, Wistar , Disease Models, Animal , Glutathione Peroxidase/analysis , Glutathione Peroxidase/drug effects , Memory/drug effects , Memory/physiology , Memory Disorders/physiopathology , Memory Disorders/metabolism , Nitrites/analysis
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