ABSTRACT
Blood lead level and its impact on haemoglobin and intelligence among school children near lead based industries, and to supplement them with a nutritious food for its effect, were studied. Blood was withdrawn from 120 children [9-12 years] and lead was estimated by Lead Care Analyzer Kit and haemoglobin by auto analyser. Culture Fair Non-verbal Test was used to assess the Intelligence Quotient. After pre-test, the experimental group [n = 60] were given nutritional supplementation for 3 months and education on hygiene measures, while the control group [n = 60] did not receive them. Food supplementation and education significantly decreased the lead level in the experimental group [8.8+/-0.5 to 6.9+/-0.4, µg/dL, mean +/- SE] but not in the control group. The intelligence score improved in the experimental group but not in the control group. A negative correlation was observed between the lead level and intelligence. No improvement was observed in the haemoglobin. This study shows that the blood lead level in children near lead based industries is high and is negatively correlated with intelligence. Supplementation of nutritious food and education on hygiene measures have decreased the lead level and increased the intelligence score
ABSTRACT
DRDE-07, a newly synthesized amifostine analog currently under clinical investigation in a phase I trial, is a potent antidote against sulfur mustard toxicity. The purpose of this research was to evaluate the pharmacokinetic profile of DRDE-07 in female Swiss Albino mice after a single oral dose of 400 or 600 mg/kg. The physicochemical properties of DRDE-07, including solubility, pK a, Log P, plasma protein binding and plasma/blood partitioning, were determined to support the pharmacokinetic characterization. DRDE-07 concentration was determined by an HPLC-UV method. The profile of plasma concentration versus time was analyzed using a non-compartmental model. Plasma protein binding was assessed using ultrafiltration. DRDE-07 appeared rapidly in plasma after oral administration with peak plasma levels (C max) observed in less than 15 min. There was a rapid decline in the plasma levels followed by a smaller second peak about 90 min after dosing. The plasma protein binding of DRDE-07 was found to be less than 25% at all concentrations studied. Plasma clearance of DRDE-07 is expected to be ~1.5 fold higher than the blood clearance of DRDE-07. The probable metabolite of DRDE-07 was identified as phenyl-S-ethyl amine.