ABSTRACT
We report a child with hypereosinophilic syndrome who presented with cardiogenic shock. In addition, she had skin and joint involvement. The clinical condition improved and eosinophil counts normalized with steroid therapy. However, the skin lesions and hypereosinophilia relapsed on stopping the steroids. The child was subsequently maintained in remission on low dose prednisolone.
Subject(s)
Anti-Inflammatory Agents/therapeutic use , Child , Exanthema/etiology , Female , Fever/etiology , Humans , Hypereosinophilic Syndrome/complications , Hypereosinophilic Syndrome/drug therapy , Prednisolone/therapeutic use , Shock, Cardiogenic/complications , Shock, Cardiogenic/drug therapyABSTRACT
We describe two cases of Reactive Hemophagocytic syndrome (RHS) occurring in rheumatic diseases in childhood. Patient 1, an adolescent girl with systemic onset Juvenile idopathic arthritis (JRA) presented like severe sepsis with shock, hepatic dysfunction and coagulopathy. Patient 2 presented with cardiac tamponade, she was later detected to have systemic lupus erythematosus (SLE). Her bone marrow aspirate revealed prominent hemophagocytosis. Both cases improved with pulse methylprednisolone therapy.
Subject(s)
Adolescent , Arthritis, Juvenile/complications , Blood Coagulation Disorders/etiology , Cardiac Tamponade/etiology , Female , Glucocorticoids/administration & dosage , Humans , Liver/physiopathology , Lupus Erythematosus, Systemic/complications , Lymphohistiocytosis, Hemophagocytic/complications , Methylprednisolone/administration & dosage , Pulse Therapy, DrugABSTRACT
A total of 5082 consecutive deliveries in Medical College Hospital, Kottayam during the period August 1992 to July 1993 constituted the study. Perinatal mortality rate (PMR) was 38.5 per 1000 total births and autopsy rate was 72%. More than 85% of perinatal deaths occured in low birth weight and preterm babies. Perinatal hypoxia and congenital anomalies were the leading causes in late fetal deaths (LFD). The main causes of early neonatal deaths (END) were perinatal hypoxia, infections, congenital anomalies and hyaline membrane disease (HMD).