ABSTRACT
The present study was undertaken to compare the effects of Melatonin 3 mg, Pregabalin 75 mg andAlprozolam 0.5 mg as premedicant drugs for reduction in perioperative anxiety and post operative pain,assessment of level of sedation. 150 patients of ASA grade I and II, between 20 - 50 years, of eithersex, undergoing laparoscopic surgery were divided into 3 groups of 50 patients each. Baseline anxietylevel and level after 1hr of drug was assessed. Also postoperative anxiety at different intervals wasassessed. Similarly postoperative pain and level of sedation at different intervals was assessed. Patients in group M were highly sedated as compared to group P and group A at all intervals and thedifference was statistically significant. All the three groups were comparable regarding postoperativepain, perioperative anxiety and side effects at all intervals and the difference was statistically insignificant at all intervals.