therapeutic trial of nitrofurantoin versus nitrofurantoin-propantheline for urinary tract infection

A double blind therapeutic trial, using randomly either nitrofurantoin or nitrofurantoin-propantheline combination was carried out on 58 patients with urinary tract infection. Nitrofurantoin alone or in combination had similar cure rate. However, nausea and / or vomiting was significantly higher in the nitrofurantoin group [P< 0.05]. Moreover, side effects in 7 patients among the later group were severe enough to stop treatment. It is suggested that adding propantheline to nitrofurantoin in the treatment of urinary tract infection, more significantly reduces the side effects