ABSTRACT
Objective: To evaluate the efficacy of repeated autologous serum injections in patients with chronic autoimmune urticarial
Methods: Patients of chronic autoimmune urticaria were prospectively analyzed for the efficacy of eight consecutive weekly autologous serum injections with a post-intervention follow-up of 12 weeks. Total urticaria severity score [TSS] was calculated at the baseline, at the end of treatment and lastly at the end of 12 weeks of follow-up. Response to therapy was judged by the percentage reduction in baseline TSS at the end of treatment and again at the end of 12 weeks of follow-up
Results: Out of the 65 patients enrolled, 4 opted out of study after one or the first few doses. Among the rest of the 61 patients, 16.4% patients showed excellent response and 55.7% showed good to fair response to autologous serum therapy. Poor response was seen in 27.9% of the study population. Among the responders, only 15.9% [out of 72] relapsed at the end of 12 weeks of follow-up and at the end of study protocol we had 60.7% of the study population who could be labeled as completely or partially remitted with the treatment regimen
Conclusion: Autologous serum therapy is an effective therapy in patients with chronic autoimmune urticaria. Better response is seen in female patients with short duration of disease
ABSTRACT
Aim : The aim of this study was to determine the value of dynamic high-resolution ultrasonography (HR-US) in the evaluation of internal derangements of a temporomandibular joint (TMJ) in the open and closed mouth position. Settings and Design : The study designed to collect the sample from the Outpatient Department of Oral Medicine and Radiology at GDC, Bangalore. Patients with pain, clicking, deviation, and tenderness were included in the study as a symptomatic group. The asymptomatic group was free of any symptoms. Materials and Methods : Maximum mandibular range of motion (Open and Closed) was performed during HR-US of TMJ in 100 consecutive patients, (50 symptomatic and 50 asymptomatic cases, a total of 400 joints, with 200 joints in the right and left closed and open mouth position;36 males and 64 females; age range, 16 - 50 years; mean age 27.56 years). Subsequently, the entire group, after clinical diagnosis, went for HR-US. Sonography confirmed the diagnosis by showing internal derangement in 34 (68%) of the symptomatic group and the remaining 16 (32%) patients failed to show any derangement. In the asymptomatic group 40 patients did not show any pathology associated with TMJ, whereas, 10 patients showed internal derangement. The data obtained was analyzed statistically. Results : HR-US performed during the maximal range of motion (Open and Closed) helped to detect 34 instances (68 joints) of internal derangement, which were true positive cases, whereas, 16 patients (32 joints) showed a false positive finding for internal derangement (ID). The results obtained showed a sensitivity of 64%, specificity of 88%, positive predictive value of 84%, and a negative predictive value of 71%, with an accuracy of 76%. Conclusions : Dynamic HR-US being non-invasive can provide valuable information about internal derangement of the TMJ in mandibular closed mouth than open mouth position.
ABSTRACT
N-(2-naphthyl)glycine hydrazide and N-methyl-N-(2-naphthyl) glycine hydrazide, which inhibit Mycobacterium tuberculosis H37 RV and show activity against experimental tuberculosis, were evaluated for their mutagenic potential in Salmonella typhimurium. Both the compounds at concentration ranges from 0·1 μg/plate to 1000 μg/plate failed to induce mutations at the histidine locus either directly or after treatment with rat liver homogenate fraction- "S-9". N-(2-naphthyl)glycine hydrazide and its N-methyl derivative elicited toxicity at concentrations of 500 μg/plate and 1000 μg/plate. However, in the presence of the liver homogenate system, reduction in toxicity was noticed probably due to detoxification and/ or conjugation of the compounds. Under the assay conditions employed, standard mutagens like 4-nitroquinoline-N-oxide, 9-aminoacridine and benzo(a)pyrene were positive. The nonmutagenic nature of N-(2-naphthyl)glycine hydrazide and N-methyl-N-(2-naphthyl)glycine hydrazide should enhance their potential for inclusion in treatment protocols for management of tuberculosis.