ABSTRACT
Mesenteric cysts are uncommon abdominal masses in children. They occur most frequently in the small bowel mesentery and often contain chylous fluid. These cysts may be multilocular, grow to huge proportions and are believed to be caused by obstructed, malformed, ectopic lymphatic tissue. The patients' clinical presentations is dependent on cyst size, location and related complications such as partial or complete bowel obstruction, perforation, peritonitis, volvulus and malignant degeneration. Surgical resection is the treatment of choice. Ultrasound and CT are the most valuable modalities for evaluating mesenteric cysts
Subject(s)
Child, Preschool , Female , Humans , Abdominal Neoplasms/diagnosis , Mesenteric Cyst/diagnosis , Lymphangioma/diagnosis , Abdominal Neoplasms/complications , Mesenteric Cyst/etiology , Diagnosis, Differential , Lymphangioma/complicationsABSTRACT
Lewis-related blood group antigens are carbohydrate determinants carried on surface glycoproteins and glycolipids of erythrocytes and some epithelial cells. Their expressions in colorectal mucosa has been considered either as a marker of differentiation antigens or of tumor associated antigens. We prospectively studied Lewis-related blood group antigens in patients undergoing colectomy for colonic adenocarcinoma. Immunohematological studies were performed on preoperative blood samples and ABO and Lewis blood groups were determined. Tissue samples were obtained from the adenocarcinoma and from the adjacent non-neoplastic mucosa. The degree of tumor differentiation (grade of the tumor) was analyzed on hematoxylin and eosin stained slides. Immunoperoxidase staining was performed using antibodies against A, B, Le(a), Le(b), Le(x), and Le(y) antigens. The staining results of the colonic carcinoma were compared with those of the non-neoplastic mucosa and with the patient's red blood cell Lewis phenotype. A total of 22 patients were studied, 12 males and 10 females, with an average age of 64 +/- 12 years. There were 12 modified Dukes B and 10 modified Dukes C carcinomas. Le(a), a marker of differentiation antigens, was expressed in the non-neoplastic mucosa of 82 per cent of the specimens. Le(y), a marker of tumor associated antigens, was detected in 77 per cent of the carcinomas while expressed only in 18 per cent of the adjacent non-neoplastic mucosa. Le(x), supposedly a marker for tumor aggressiveness, was found in 55 per cent of the carcinomas. However, it was virtually absent in the five carcinomas which did not invade the pericolic tissues