ABSTRACT
Inflammation plays an important role in all stages of inflammation and it appears to be a pivotal component of the process the transform stable to unstable disease because an augmentation of the inflammatory activity takes place during ACS. To study benefits of statins in treatment of unstable angina and non ST segment elevation myocardial infarction during the early days of hospital admission through its anti-inflammatory effect regardless cholesterol level. This study included 50 patients who were divided into two groups, atorvastatin group [group I] [25 patients] and control group [group II] [25 patients]. All patients were subjected to 12 lead electrocardiography, routine laboratory investigations including total cholesterol, LDL-C, HDL-C, triglycerides ,CRP and titre on admission, at the 6[th] and 14[th] day ,also, CPK and CKMB were measured on admission, after 6, 24 and 48 hours respectively. All patients received the traditional treatment of unstable angina and non ST segment elevation myocardial infarction, Atorvastatin 20 mg/day was administered to group I from the first day and continued during the period of follow up. CRP levels decreased significantly at the 6[th]day and 14[th] day in group [I] and increased significantly at the 6[th] day in group [II].Atorvastatin lowered the level of T.C, HDL-C, TO and this decrease was significant as regards LDL-C and TO and increased HDL-C significantly by the end of 14 days. There was no correlation between CRP changes and lipid profile changes. The result of the current study showed that atorvastatin 20 mg had anti- inflammatory effect in addition to its lipid lowering effect appeared in the early days after anti-inflammatory effect appeared in the early days after administration so starting of atorvastatin therapy immediately on admission in patients with UA or NSTEMI, regardless their lipid levels is recommended