computational structural analysis of functional attributes of hypodermin A and B proteins: a way forward for vaccine development

Hypodermosis is a parasitic disease of cattle. The pathogenicity of the disease is attributed to Hypodermin proteins [Hypodermin A, Hypodermin B and Hypodermin C]. Studies suggest that Hypodermin proteins may be defined as Serine proteases and collagenases. The structure of both proteases Hypodermin A and Hypodermin B were modeled using the Swiss-model server followed by its validation using Procheck, Errat and Verify-3D. Afterwards, both Hypodermin A and Hypodermin B were docked against collagen in order to study its interaction with respective Hypodermin proteins. The structure of both Hypodermin A and Hypodermin B showed more bent towards hydrophobic nature, as more beta sheets were present in them. Both structures were also superimposed to check out similarities and differences present between them. Serine, Aspartic acid, Histidine, Glutamic acid and Lysine are found as interacting residues that are involved in hydrogen bonding with collagen. The interactions are found in the active domain region of Hypodermin proteins. The interacting residues were present in the active region of the hypodermin proteins thus validating the docking studies. This study may help in the drug development against hypodermosis with least side effects

Formulation and in vitro evaluation of colchicines and naproxen sodium sustain release tablets in combination for treatment of gout

Present investigation concern with combination of two drugs for the treatment of gout. One of these drug [naproxen sodium] is pain killer which is sustain their action within the body for 12 hours and the other drug [colchicine] is anti-gout, which release as conventional dosage. After oral administration naproxen will act as sustain release dosage and increase patient compliance about six batches of tablet were developed and evaluate .For the sustain release action polymers Methocel K4M and HPMCK15were used. These polymers were used in combination used with other inactive ingredients. Two methods were used for proration of final tablets. In 1[st] method only naproxen sodium granules were prepared which are sustained released. In second method these granules were mixed with colchicines powder and other all inactive ingredients. This method is easy and cost effective characterization of pallets and final tablets were performed. Final tablets were evaluated for all tests like appearance, friability, dissolution, hardness, assay, weight variation and in-vitro release study performed. The results obtained were satisfactory and complies with USP specification. Formulation containing combination of Methocel K4M and HPMC K15 showed good sustain release profile for 12 hours

Exact solutions of a second-grade fluid via inverse method

In this paper, we present the exact solutions for the equations of motion of a viscous incompressible second-grade fluid. The exact solutions are constructed for steady and unsteady equations by employing inverse method

Riabounchinsky type steady flows of an incompressible fluid of pressure-dependent viscosity

Riabounchinsky type steady plane flows of an incompressible fluid of pressure-dependent viscosity are indicated. An application of a solution is also presented, and velocity profile are also plotted for different values of constant d[1]

Some similarity solutions of inviscid compressible fluid flow equations

Employing one parameter group of transformation some new exact solutions of the equations governing the steady inviscid compressible fluid are determined. Some of the solutions involve arbitrary function enabling us to construct a large number of solutions of the flow equations. The streamline patterns of some of the solutions in unbounded and bounded regions are also presented

Some analytic solutions of the unsteady Navier-stokes Equations

The unsteady Navier-Stokes equations are transformed into steady state equations using lie group theory. The solutions of the steady state equations are determined for the flows for which the vorticity is proportional to psi perturbed by a uniform flow U y and or the flows characterized by y = R[x] + v[psi] and y = Q[x] v[psi]. For some flows streamline patterns are also presented

numerical method for the solution of linear second order boundary value problem

A numerical method for solving the second order linear boundary value problems is presented. The method is tested on twenty B.V.P's and it is found that numerical and exact solutions are in good agreement