ABSTRACT
Background: ovarian cancer is the second most common gynecological cancer and the fifth most common cancer in women. Proper management depends on proper preoperative assessment with the help of clinical examination, laboratory tests and different imaging modalities. Radiological evaluation includes ultrasonography [US], computed tomography [CT] and recently magnetic resonance imaging [MRI]. Diffusion weighted imaging [DWI] has been established as a useful functional imaging tool in neurologic applications for a number of years, but recent technical advances now allow its use in abdominal and pelvic applications
Purpose: it was to evaluate the role of diffusion weighted and perfusion weighted MRI imaging in the characterization of ovarian tumours and differentiation between benign and malignant tumours
Patients and Methods: this study was performed on 24 patients. All patients had US finding of solid or complex adnexal lesions
Results: DWI and dynamic MRI are significant promising tool factors for characterization of ovarian tumours and differentiation between benign and malignant lesions with high sensitivity, specificity. The sensitivity, specificity and accuracy of detection of the nature of the lesions. Have been increases after adding of DWI and DCE-MRI to the conventional imaging
Conclusion: Adding of DWI and DCE-MRI to the conventional MRI improves the sensitivity and specificity of diagnosis and allows confident diagnosis and differentiation between benign and malignant lesions
ABSTRACT
The aim of the present study was to evaluate the diagnostic value of serum cystatin-C [Cys-C] as a serum marker of glomerular filtration rate [GFR] in patients with various renal diseases with a wide range of renal function as well as to compare between serum Cys-C, creatinine and beta 2-microglobulin [beta 2m] as indicators of GFR. The study included 63 patients [39 males and 24 females aged between 17 and 75 years]. Serum Cys-C was measured by automated particle- enhanced turbidimetry, serum creatinine by Synchron CX-7 autoanalyzer, serum beta 2m by enzymognost beta 2m assay and GFR by 99m Tc-labeled diethylenetriamine pentaacetic acid [99m TcDTPA] clearance. The results demonstrated that serum Cys-C significantly increased in patients with reduced GFR [less than 80ml/min], while serum creatinine and serum beta 2m were significantly increased at a later stage of renal insufficiency at GFR [less than 40ml/min]. The sensitivity and diagnostic accuracy of Cys-C were better than that of serum creatinine and beta 2m