ABSTRACT
Introdução: Estudos epidemiológicos de base hospitalar sobre o câncer infantojuvenil são importantes para mostrar o perfil dos pacientes assistidos pelo serviço. Objetivo: Avaliar o perfil clínico-epidemiológico e a sobrevida d e pacientes na faixa etária de 0-19 anos atendidos no Hospital do Câncer de Cascavel Uopeccan (2000-2014). Método: Estudo transversal com avaliação de prontuários para os seguintes desfechos: sexo, idade, cor/raça, outras patologias, histórico familiar de câncer, domicílio, tipo da neoplasia, estadiamento, tratamento, metástases, recidivas, situação do paciente ao final da pesquisa. A estatística descritiva e os testes qui-quadrado e Kaplan-Meier foram aplicados. Resultados: Observou-se maior frequência para meninos (55,2%), faixa etária de 1-4 anos (36,3%), brancos (87%), domicílio urbano (81,6%), leucemia (35,8%) e quimioterapia (50,2%). Ocorreu metástase em 16,41% e recidiva em 22,38%. Não havia relato de histórico familiar de câncer em 47% dos prontuários. Outras patologias foram negadas em 58,9%. Ao final, 55,2% estavam vivos e sem doença. Houve associação estatisticamente significava entre menores de 10 anos com tumores renais e neuroblastoma; maiores de 10 anos com linfomas e neoplasias epiteliais malignas; e entre a situação atual do paciente com metástase, recidivas e estadiamento. Conclusão: Os pacientes analisados na presente pesquisa eram na maioria leucêmicos, do sexo masculino e faixa etária de 1-4 anos. A sobrevida global e a livre de doença foram, respectivamente, de 70,3% e 71,63%
Introduction: Hospital-based epidemiological studies on childhood cancer are important to show the profile of patients cared by the service. Objective: To evaluate the characteristics of cancer patients aged 0-19 years at the Cascavel Cancer Hospital Uopeccan (2000-2014). Method: Cross-sectional study that evaluated medical charts for the following outcomes: gender, age, color/race, comorbidities, family history of cancer, household, cancer type, staging, treatment, metastasis, recurrences, patient's status at the end of study. Descriptive statistics, chi-square and Kaplan-Meier were applied. Results: Boys were more prevalent (55.2%), age range from 1 to 4 years (36.3%), White (87%), urban household (81.6%), with leukemia (35.83%) and in chemotherapy (50.2%). Metastasis occurred in 16.41% and recurrence in 22.38%. There was no report of family history of cancer in 47% of the charts. Other pathologies were denied in 58.9%. In the end, 55.2% were alive and disease-free. There was a statistically significant association between boys younger than 10 years old with renal tumors and neuroblastoma and older than 10 years with lymphomas and malignant epithelial neoplasms and between the current status of the patient with metastasis, relapses, and staging. Conclusion: The patients analyzed in this study were mostly leukemic, males and aged 1-4 years. Global and disease-free survival were, respectively, 70.3% and 71.63%
Introducción: Los estudios epidemiológicos hospitalarios sobre cáncer infantil son importantes para mostrar el perfil de los pacientes atendidos por el servicio. Objetivo: Evaluar las características de los pacientes oncológicos de 0-19 años atendidos en el Hospital do Cáncer de Cascavel Uopeccan (2000-2014). Método: Estudio transversal que evaluó historias clínicas para los siguientes resultados: sexo, edad, color/raza, comorbilidades, antecedentes familiares de cáncer, domicilio, tipo de cáncer, estadificación, tratamiento, metástasis, recurrencias, situación del paciente al final de la investigación. Se aplicó estadística descriptiva, chi-cuadrado y Kaplan-Meier. Resultados: Fueron más prevalentes: niños (55,22%), grupo de edad 1 a 4 años (36,32%), blancos (87,06%), hogares urbanos (81,59%), leucemia (35,83) %) y quimioterapia (50,25%). Hubo metástasis en 16,41% y recidiva en 22,38%. No hubo informes de antecedentes familiares de cáncer en 47% de los pacientes. Se negaron comorbilidades en 58,91%. Al final, 55,23% estaban vivos y sin enfermedad. Hubo asociación estadística entre menores de 10 años con tumores renales y neuroblastoma; mayores 10 años con linfomas y neoplasias epiteliales malignas; e entre la situación del paciente con metástasis, recaídas y estadificación. Conclusión: Los pacientes analizados en esta investigación eran en su mayoría leucémicos, varones y de 1 a 4 años. La supervivencia global y libre de enfermedad fueron, respectivamente, 70,3% y 71,63%
Subject(s)
Humans , Male , Female , Child , Adolescent , Epidemiologic Studies , Survival Analysis , Adolescent , NeoplasmsABSTRACT
Aim: To characterize the patterns of dental anomalies (DA) in the mixed and permanent dentitions of patients with nonsyndromic oral cleft (NSOC). Methods: This cross-sectional, observational, case-control study included 173 patients, 61 with mixed dentition (NSOC=29 and control=32) and 112 with permanent dentition (NSOC=57 and control=55). All subjected were submitted to clinical and radiographic examination. Dental anomalies of eruption, number, size and shape outside the cleft area were considered. Results: Although there was no statistical significance among patients with mixed dentition, dental agenesis was the anomaly more common in this group. In patients with permanent dentition, a higher prevalence of DA in NSOC group compared to control group was observed (p=0.02). Gyroversion and dental agenesis were the DA more frequently observed in the permanent dentition and the second premolar was the tooth more affected (p=0.003). Mandible and the left side were more involved, and dental agenesis was more frequently found in patients with unilateral cleft lip with or without cleft palate (NSCL±P). Conclusion: Our findings show a higher frequency of DA in NSOCs than in the control group in patients with permanent dentition, mainly due to a higher occurrence of agenesis of second premolars in patients with unilateral NSCL±P