ABSTRACT
Thallium acetate [TI] is a cumulative poison intimately accompanied by an increase in reactive oxygen species [ROS] formation that represents an important risk factor for tissue injury and malfunction. This study aims to determine the possible hepatoprotective and antioxidant effects of diallyl sulfide [DAS] from garlic and curcumin from turmeric against TI-induced liver injury and oxidative stress [OS] in rats. This in vivo animal study divided rats into six groups of 8 rats per group. The first group received saline and served as the control group. The second and third groups received DAS or curcumin only at a dose of 200 mg/kg. The fourth group received TI at a dose of 6.4 mg/kg for 5 consecutive days. The fifth and sixth groups received DAS or curcumin orally 1 hour before TI intoxication at the same dose as the second and third groups. Liver integrity serum enzymes aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase [ALP], lactate dehydrogenase [LDH], and ?-glutamyltransferase [?-GT] were evaluated. Serum and liver tissue homogenate lipid peroxidation and OS biomarkers were measured. The data were analyzed by one-way ANOVA followed by Duncan's multiple range test for post hoc analysis using SPSS version 16. TI induced marked oxidative liver damage as shown by significantly [P