Evaluation of histopathological and biochemical hepatoprotective potentials of fagonia bruguieri a plant from Cholistan desert

Aerial parts of Fagonia Bruguieri [FB] [family, zygophyllaceae] were subjected to in vivo hepatoprotective study in order to validate its traditional use in hepatobiliary disorders, by native people of Cholistan desert, Pakistan. Experimental study. This study was conducted at PCR lab Multan. The animals were randomly divided into three groups, containing 10 rabbits in each group. Hepatoprotective effects of pre-treatment with aerial parts [ethanolic extract] of FB [500 and 750 mg/kg/day PO for 7 days] against CC1[4] [0.75 ml/kg, S/C] intoxicated rabbits were evaluated by serum biochemical parameters and liver histological observations. Silymarin [100 mg/kg/day PO for 7 days] was used as a standard hepatoprotective drug, CC1[4] intoxicated group had raised levels of SCOT, SGPT and ALP sTignificantly but TB level was not raised as compared to normal control group. FB extract [both doses of 500 and 750 mg/kg] showed hepatoprotection as obvious by significant reinstatement of levels of SCOT, SGPT and ALP while TB level was not changed significantly, when compared with CC1[4] intoxicated group. B[oth] doses of FB extract were well comparable with silymarin. Histopathological examination of the liver tissue further corroborated these results. Therefore, the conclusion of the present study supports the traditional believes on hepatoproptective effects of Fagonia Bruguieri [aerial parts]

Risk factors and microbiologic profile in catheter related urinary tract infection

To describe the consequences of uretheral catheterization in terms of the incidence of catheter related infection, duration of catheterization relation with UTI and changes in microbiologic pathogens. May 2006 to August 2006. Only 214 were included in final analysis, 28 were excluded from the study because these patients expired before the observable endpoint, these were critically ill. Adult patients in whom are indwelling foley's catheter was inserted with past 24 hours at the Emergency Room, Urology Wards, male and female surgical wards, medical wards, orthopedics wards, gynaecology wards, pediatrics wards, neurosurgery wards and ICU of Nishtar Hospital, Multan and Bakhtawar Amin Memorial Trust Hospital, Multan were included in the study. Out of 110 patients who acquired UTI, [83 single bacterial infection, 16 with pure candidal infection, 6 with double bacterial infection and 5 with both bacteria and yeast]. Majority of the isolated organisms were gram negative bacilli [66.9%]. E. coli being the most common [27] followed by Kiebsiella SP [26]. Other gram negative organisms isolated were acinetobactor SP [12], pseudomonas aeruginaosa [8], Enterobactor SP [6] and proteus Sp [2]. Ninteen [15.7%] were gram positive organisms, Enterococcus [9], coagulase negative staphococcus [7] and staphylococcus aureus [3]. Candida spieces were recovered in 17.4% of isolates. Fifty five percent of E. coli were isolated at 2 days post-catheterization while majority of the other organisms were isolated at more than 2 days after catheterization

Association of blood group A with increased risk of coronary heart disease in the Pakistani population

Many reports have appeared in recent years showing an association between blood groups and cardiovascular diseases. Clinical studies in developed countries have shown that individuals of the A blood group phenotype are more susceptible to Coronary Heart Disease [CHD]. The present study was designed to investigate the correlation of ABO blood groups and CHD in the South Asian population. 252 CHD patients and 75 healthy controls were recruited from Karachi and Nawabshah, Pakistan. The results obtained in this study show that the prevalence of CHD in blood group A is invariably higher than in all other ABO blood groups. It is striking that despite the fact that the most prevalent blood group among Pakistanis is phenotype B, the incidence of CHD is highest in individuals with blood group phenotype A. This suggests that a certain CHD risk is associated with phenotype A. Thus, we conclude that, in the Pakistani cohort investigated in the present study, blood group phenotype A is associated with a substantially increased risk for CHD, which seems independent of conventional cardiovascular risk factors

Association of blood group A with increased risk of coronary heart disease in the Pakistan population

Many reports have appeared in recent years showing an association between blood groups and cardiovascular diseases. Clinical studies in developed countries have shown that individuals of the A blood group phenotype are more susceptible to Coronary Heart Disease [CHD]. The present study was designed to investigate the correlation of ABO blood groups and CHD in the South Asian population. 252 CHD patients and 75 healthy controls were recruited from Karachi and Nawabshah, Pakistan. The results obtained in this study show that the prevalance of CHD in blood group A is invariably higher than in all other ABO blood groups. It is striking that despite the fact that the most prevalent blood group among Pakistanis is phenotype B, the incidence of CHD is highest in individuals with blood group phenotype A. This suggests that a certain CHD risk is associated with phenotype A. Thus, we conclude that, in the Pakistani cohort investigated in the present study, blood group phenotype A is associated with a substantially increased risk for CHD, which seems independent of conventional cardiovascular risk factors