Formulation design of Aceclofenac microcapsules by inotropic gelation technique, characterization studies and release kinetics.

Osteoarthritis predominantly affects the large weight bearing joints and the clinical characteristics include morning stiffness of short duration, stiffness or gelling on rest, pain on use, joint inflammation and bone deformity. Microcapsules of aceclofenac were formulated with methyl cellulose, sodium CMC and hydroxyl propyl methyl cellulose by technique. The microcapsules showed excellent rheological properties for all batches. The formulations showed drug content uniformity with high drug entrapment efficiency. The in vitro wash off test revealed the mucoadhesive ability of the micro capsules. Scanning electron microscopy indicated structural and surface morphology uniformity. The in vitro release studies indicated sustained release of aceclofenac from the formulations. Kinetic study of the release data indicated the zero order release and non fickian sustained release mode of drug release. The microcapsules showed the correlation between wall thickness and drug release pattern.

Opportunity for natural selection among three endogamous subpopulations of Andhra Pradesh.

The Crow's index of opportunity for natural selection has been calculated for three endogamous subpopulations namely Arya Vysya, Thrivarnika and Kalinga Vysya of North Coastal Andhra Pradesh. The total index is in the order Arya Vysya > Thrivarnika > Kalinga Vysya. However, the mortality component is more in Kalinga Vysya, reflecting the poor medical facilities available to them due to their low socio- economic profile compared to other two populations. The results of the present study are compared with those among the other caste populations of Andhra Pradesh.

Selection intensity among Kshatriyas an endogamous population of Andhra Pradesh.

Opportunity for natural selection has been studied among the women of Kshatriya caste population from rural and urban areas of north coastal Andhra Pradesh. The urbanrural difference for different demographic characteristics is not significant. The contribution of fertility component for both Crow's index and Jonston and Kensinger's index is more. The present study is compared with other Andhra populations. The decreased mortality differentials in Kshatriyas suggest that this component was directly affected by the better socio-economic level and reflects on the population's transitional phase.