ABSTRACT
Pharmacoscintigraphy is a non-invasive technique for determining the fate of drugs after administration into humans. Collecting valuable information through the pharmacoscintigraphyabout absorption and release mechanisms of drugs from formulations, and thus proving to be an invaluable tool in developing newer and more effective formulations. Such studies can be used to determine the behavior of drugs, formulation as well as diagnostic agents that are administered. In this technique, radiolabelled formulations are administered to patients by their intended route of administration. Their transit through the body is monitored using sophisticated imaging cameras. Since the amount of radiotracer that is used is very low, this is a safe, efficient, and accurate method for studying the behavior of drugs in the human body. Preclinical studies of newer drugs have successfully been carried out using the pharmacoscintigraphic technique
ABSTRACT
Super porous hydrogels (SPHs) basically developed initially create as a novel drug delivery system to absorb and continue to hold the drugs in the gastric medium which allows absorption in stomach and upper part of the gastrointestinal tract. These systems get swollen in the stomach instantly and in the harsh stomach environment they maintain their integrity, while the pharmaceutical active ingredient is being released. Instant and fast swelling property of hydrogel is based on water absorption through open porous structure by capillary force. SPHs have the poor mechanical strength which has got over by developing the second-generation SPH composites (SPHCs) and the third-generation SPH hybrids (SPHHs). The present review has been focused on the preparation, characterization and application of SPHs