ABSTRACT
Objective To analyze the clinical manifestations,bacterial resistance to antibiotics and risk factors of mortality in pneumonia patients with Acinetobacter baumannii(AB) positive in respiratory secretions.Methods Clinical datas of pneumonia patients with AB positive in respiratory secretions in ICU from June 2012 to June 2017 were analyzed.According to the 28 day survival after diagnosis,the patients were divided into death group and survival group.Univariate and multivariate Logistic analysis were used to examine the risk factors of AB positive patients.Results This study included 98 patients.The 28 day mortality was 54.1％.The independent risk factors of mortality were:merge coronary heart disease(OR =38.3,95％ CI:1.81-720.10,P =0.019),high APACHE Ⅱ score (OR =3.47,95％ CI:1.30-12.81,P=0.043),prolonged APTT(OR =1.32,95％ CI:1.03-1.71,P=0.037),high levels of PCT(OR=2.78,95％ CI:1.30-7.02,P =0.023).APACHE Ⅱ scores and patients died from AB culture positive time was significantly negative correlation,r =-0.601,P =0.000.Whether the application of antibiotics for AB was not clearly affected by the prognosis.Conclusion Merge coronary heart disease,high APACHE Ⅱ score,prolonged APTT,high levels of PCT are independent risk factors for AB culture positive patients.In particular,merge coronary heart disease and the severity of the underlying disease determine the patient's prognosis.
ABSTRACT
Objective To explore the difference of plasma pentraxin 3 (PTX3) levels in acute coronary syndrome (ACS) patients,and to evaluate the correlation between plasma PTX3 levels and ACS as well as hypersensitive C-reaction protein (hs-CRP), through detecting the plasma levels of PTX3 and serum levels of hs-CRP in ACS patients, stable angina pectoris (SAP) patients and normal controls. Methods According to coronary angiography results,78 subjects were divided into control group (n = 20), stable angina pectoris (SAP) group (n = 22), and acute coronary syndrome (ACS) group (n = 36). The plasma levels of PTX3 and serum hs-CRP as well as routine blood biochemical markers were detected on the second day after admission. SPSS10.0 was used for one-factor analysis of variance and Logistic regression analysis. Results The logarithm level of plasma PTX3 in ACS group was significantly higher than that of the other two groups (P <0.05). The difference between the SAP group and the control group was not statistically significant (P > 0.05). Logistic regression analysis revealed that the estimated value of the plasma PTX3 logarithm level was 2.32 (P < 0.05), that of the serum hs-CRP was 0.447 (P > 0.05). Conclusion The plasma PTX3 level in ACS group is significantly higher than that of the SAP group and the control group. The correlation between plasma FTX3 levels and the ACS is stronger than that of the serum hs-CRP levels.