ABSTRACT
FNAC is widely accepted as the most accurate, sensitive,specific and cost affective diagnostic procedure in theassessment of thyroid nodules and helps to select people preoperative for surgery. The purpose of this study was toevaluate the accuracy of FNAC for diagnosis of malignancy inlong standing multinodular goiter and histopathological corelation. I evaluated the cytological and histological results of105 patients, who were underwent pre-operative FNAC andsubsequent surgery followed by post-operative histopathology.The cytological diagnosis was classified as- benign, suspiciousand malignant. The definitive cytological study showed benignlesion 92, suspicious 2 and malignant 11 among 105 patients.Post-operative histopathology study showed malignant lesion 9and 96 were benign, among the malignant lesion- 4 werefollicular variant of p. carcinoma and 4 were direct papillarycarcinoma. Benign lesions were distributed as 94 multinodulargoiter and 2 follicular adenoma. In FNAC- eleven patients werefound to be malignant but on post-operative histopathologyexamination confirmed 8 of them as malignant and 3 of themwere benign, 2 follicular adenoma and 1 multinodular goiter. 94patients were found to be benign in FNAC but post-operativehistopathology examination confirmed 93 as multinodular goiterand 1 papillary carcinoma. So total number of malignancyfound in post-operative histology is (8+1)= 9. Rest of them 96were benign. So there is discrepancy between 2 cases. So mystudy revealed a cytological and histological discrepancy in 2patient out of 105 patients due to either diagnostic or samplingerror.