ABSTRACT
Background: The sciatic Nerve can rarely be separated into tibial and common fibular Nerve within the Pelvis. In such cases the tibial nerve and common fibular nerve leave the pelvis through different routes. Materials and Method: The variation found during routine dissection for MBBS students in a 30 yr old male cadaver in the department of Anatomy, JJM Medical college Davangere, Karnataka, India. Results: The variation is High division of sciatic Nerve unilaterally on right side in 30yrs old male cadaver. Common peroneal Nerve is found passing between the two divisions of bifid piriformis while tibial Nerve passed below the inferior piriformis Conclusion: Knowledge of this variation is important clinically in sciatic nerve entrapment resulting in nondiscogenic sciatica and also requires reviewing of the piriformis syndrome
ABSTRACT
This study reports the antiteratogenic effects of caffeine on various anomalies on Charles Foster rat foetuses. The antiteratogenic activity of caffeine was assessed against two teratogens, cyclophosphamide and tolbutamide, both having different teratogenic potentials. External, visceral, and skeletal anomalies were assessed among the foetuses of both control and treated groups. Controls showed 2.5%, 0.0% and 5% external, visceral, and skeletal anomalies respectively. The offspring of caffeine-treated females showed 2.43% and 4.36% of external and visceral anomalies, while there were no skeletal anomalies. Foetuses of females treated with caffeine-tolbutamide combination showed 4.34% and 9.09% external and skeletal anomalies, which were comparatively higher than the control and caffeine-treated subgroups. However, no visceral anomalies were seen in this group. The offspring from dams treated with tolbutamide showed the highest incidence of external, visceral, and skeletal anomalies (10%, 4.6% and 13.04%) respectively. This preliminary study reveals that caffeine at dose levels of 12.5 mg/kg body weight has a protective effect on tolbutamide-treated foetuses. No foetuses could be obtained for the study of anomalies from the cyclophosphamide-treated dams because of total resorption.