ABSTRACT
Plasma cell leukemia is a rare variant of multiple myeloma and this term is applied when the absolute plasma cell count is greater than 2x10⁹ /L or the relative plasma cell number is greater than 20% of the peripheral white blood cells. PCL may be primary or secondary. A 55 year old male presented to our outpatient department with complaints of lower back pain for four months, low grade fever off and on for two months, generalised weakness and loss of appetite for 20 days without prior history of multiple myeloma. His peripheral blood smear showed 26% plasmacytoid cells and bone marrow revealed predominantly plasma cell population (80%) with binucleate and trinucleate forms. Chemotherapy was started but unfortunately patient had expired. This case is presented due to its rare occurrence, presence of organomegaly and poor outcome.