ABSTRACT
@#Introduction: Despite several techniques for corrective osteotomy in congenital radioulnar synostosis (CRUS) the published literature lacks a guide for radiographic planning and rationale for the site and level of the osteotomy. The primary objective of this study is to report a technique of radiographically controlled corrective osteotomy using the axis of rotation of the forearm in CRUS. Materials and methods: Children with CRUS underwent corrective osteotomy based on radiographic planning; the extent of rotational correction and functional outcomes were assessed at a mean of 27 months after the operation. Results: Seven forearms in six children of an average of 6.25 years were assessed for correction and functional outcomes. The average pre-operative pronation deformity was 71.5°. The average correction achieved was 64°. At follow-up, there were five excellent and two good functional outcomes. All children could perform daily tasks besides eating with hand and personal hygiene. Conclusion: Radiographic determination of the osteotomy sites by the method described is effective, consistent, and reproducible in achieving optimal functional outcomes in congenital radioulnar synostosis.
ABSTRACT
Aim: This study aims to evaluate the effectiveness and safety of teneligliptin when switched from other gliptins in patients notcontrolled on oral antidiabetic drugs in Type 2 diabetes mellitus (T2DM).Methodology: Data of T2DM patients who were switched from other gliptins to teneligliptin uncontrolled by dual or triple drugtherapy. Data of at least 3 months were collected from hospital records and analyzed. Efficacy was evaluated by the changesin fasting blood sugar (FBS), postprandial blood sugar (PPBS), and hemoglobin A1c (HbA1c) from the baseline.Results: A total of 97 patients’ data were collected and were analyzed. The mean age of the patients was 59.9 years andmean duration of diabetes was 16 years. Hypertension (61.9%) was the common comorbid condition with diabetes. Sitagliptinwas most prescribed dipeptidyl peptidase-4 (DPP-4) inhibitors with 65 (67%) patients with a mean dose of 88.5 mg, followedby vildagliptin with 10 (10.3%) patients was prescribed with a mean dose of 95 mg. Metformin and glimepiride were the mostcommon combination used with these DPP-4 inhibitors 91 (93.8%) patients and 69 patients (71.1%) were prescribed, respectively.There was a significant reduction in FBS, PPBS, and HbA1c from the baseline with a difference of 45 mg/dL, 102 mg/dL, and1.6%, respectively, after switching to teneligliptin from other gliptins. Teneligliptin was well tolerated and no serious adverseevents were reported.Conclusion: Teneligliptin was effective in significantly reducing FBS, PPBS, and HbA1c when switching from other gliptins inT2DM patients not controlled with other antidiabetic agents. The drug was well tolerated and no serious adverse events werereported.