ABSTRACT
Isoniazid (INH) is an integral component of treatment of tuberculosis. An acute overdose is potentially fatal and is characterized by the clinical triad of repetitive seizures unresponsive to the usual anticonvulsants, metabolic acidosis with a high anion gap and coma. The diagnosis of INH overdose should be considered in any patient who presents to emergency medical services (EMS) with the triad. We report a patient presenting with multiple generalised tonic clonic (GTC) convulsions with severe metabolic acidosis as a manifestation of INH toxicity. ©
ABSTRACT
Isoniazid (INH) is an integral component of treatment of tuberculosis. An acute overdose is potentially fatal and is characterized by the clinical triad of repetitive seizures unresponsive to the usual anticonvulsants, metabolic acidosis with a high anion gap and coma. The diagnosis of INH overdose should be considered in any patient who presents to emergency medical services (EMS) with the triad. We report a patient presenting with multiple generalised tonic clonic (GTC) convulsions with severe metabolic acidosis as a manifestation of INH toxicity. ©
Subject(s)
Acidosis/chemically induced , Acidosis/diagnosis , Acidosis/drug therapy , Adult , Antitubercular Agents/adverse effects , Bicarbonates/administration & dosage , Bicarbonates/therapeutic use , Buffers , Diuretics, Osmotic/therapeutic use , Female , Humans , Isoniazid/adverse effects , Mannitol/administration & dosage , Mannitol/therapeutic use , Pyridoxine/administration & dosage , Pyridoxine/therapeutic use , Status Epilepticus/chemically induced , Status Epilepticus/diagnosis , Status Epilepticus/drug therapy , Vitamin B Complex/administration & dosage , Vitamin B Complex/therapeutic useABSTRACT
Two cases are reported in which depression was associated with the use of calcium channel blocker, nifedipine. In one instance, a patient became unresponsive to treatment with nortriptyline when nifedipine was introduced. In both cases, the depression resolved following discontinuation of nifedipine.
Subject(s)
Calcium Channel Blockers/adverse effects , Depression/chemically induced , Female , Humans , Hypertension/drug therapy , Male , Middle Aged , Nifedipine/adverse effectsSubject(s)
Colon/abnormalities , Diagnosis, Differential , Electrocardiography , Humans , Hypertension/complications , SyndromeABSTRACT
We report a rare case of Alprazolam poisoning presented with coma and respiratory depression in a young girl with positive family history of suicidal attempts by her father, mother and sister. The Alprazolam was available in large amount in form of "Physicians Samples" as her elder sister was a medical representative. The patient was successfully managed.
Subject(s)
Adult , Alprazolam/poisoning , Anti-Anxiety Agents/poisoning , Coma/chemically induced , Female , Humans , Respiratory Insufficiency/chemically induced , Suicide, AttemptedSubject(s)
Adolescent , Adult , Animals , Bites and Stings/complications , Child , Female , Humans , India/epidemiology , Male , Middle Aged , Rabies/prevention & control , WolvesABSTRACT
A sporadic case of Ehlers-Danlos syndrome associated with atlantoaxial dislocation, mitral valve prolapse and dental abnormalities is presented. This case could not be assigned to any of the nine defined types of the syndrome.