ABSTRACT
OBJECTIVE@#To evaluate antidiabetic activity of chloroform extracts of Acacia arabica bark, Benincasa hispida fruit, Tinispora cordifolia stem, Ocimum sanctum areal parts and Jatropha curcus leaves.@*METHODS@#The chloroform extracts of Acacia arabica bark, Benincasa hispida fruit, Tinospora cordifolia stem, aerial part of Ocimum sanctum and Jatropha curcus leaves were evaluated at different doses (250 and 500 mg/kg body weight.) for antidiabetic potentials in alloxan induced diabetic albino rats. The extracts were administered for two weeks in different groups whereas tolbutamide (80 mg/kg body weight) was used as reference standard throughout study.@*RESULTS@#The result of present study showed test compounds significantly decreases elevated level of serum glucose and also caused to reverse the cholesterol, triglyceride, HDL and LDL values when compared to untreated diabetic rats.@*CONCLUSIONS@#Our finding indicates that different test extracts were able to ameliorate the derangements in lipid metabolism caused by diabetes mellitus in alloxan induced diabetic rats towards normal level.
Subject(s)
Animals , Male , Rats , Blood Glucose , Cholesterol , Blood , Diabetes Mellitus , Drug Therapy , Disease Models, Animal , Hypoglycemic Agents , Pharmacology , Lipoproteins, HDL , Blood , Lipoproteins, LDL , Blood , Plant Extracts , Pharmacology , Plant Leaves , Chemistry , Plant Stems , Chemistry , Plants, Medicinal , Chemistry , Triglycerides , BloodABSTRACT
Asthma is a common disease that is rising in prevalence worldwide with the highest prevalence in industrialized countries. Asthma affects about 300 million people worldwide and it has been estimated that a further 100 million will be affected by 2025. Since the ancient times, plants have been exemplary sources of medicine. Current asthma therapy lack satisfactory success due to adverse effect, hence patients are seeking complementary and alternative medicine to treat their asthma. Ayurveda and other Indian literature mention the use of plants in various human ailments. India has about 45,000 plant species and among them several thousand are claimed to possess medicinal properties. Researches conducted in the last few decades on the plants mentioned in ancient literature or used traditionally for asthma have shown antiasthmatic, antihistaminic and antiallergic activity. This review reveals that some plants and their extract have antiasthmatic, antihistaminic, anticholinergic and antiallergic activity.
Subject(s)
Humans , Anti-Asthmatic Agents , Asthma , Drug Therapy , Medicine, Ayurvedic , Plant Extracts , Plants, MedicinalABSTRACT
<p><b>OBJECTIVE</b>To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL).</p><p><b>METHODS</b>Antinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100, 125 and 150 mg/kg bw.</p><p><b>RESULTS</b>The results indicated that MRCL exhibited considerable antinociceptive activity against three classical models of pain in mice. Preliminary phytochemical analysis suggested the presence of saponin, steroids and alkaloids.</p><p><b>CONCLUSIONS</b>It can be concluded that MRCL possesses antinociceptive potential that may be due to saponin, steroids and alkaloids in it.</p>