ABSTRACT
Abstract Mucopolysaccharidosis (MPS) is a heterogeneous group of rare, chronic, progressive and systemic inherited disorders resulting from deficiency or lack of lysosomal enzymes responsible for the degradation of glycosaminoglycans. Products of nitrosative stress have been previously detected in blood and urine samples of patients with MPS. However, it is unclear whether they are present in the saliva of MPS patients and also if they correlate with salivary parameters such as flow and pH. This study compared the salivary levels of NOX (NO2- + NO3-), nitrite (NO2-), protein (albumin), erythrocyte and leukocyte numbers, as well as the salivary flow rate and pH values of samples obtained from 10 MPS patients and 10 healthy subjects. MPS patients exhibited higher salivary levels of NOX and NO2- when compared to healthy subjects (p < 0.05). Albumin was only detected in six saliva samples of MPS patients and, erythrocytes and leukocytes were detected in 60% and 40% of the MPS patients, respectively. In addition, salivary flow rate and pH averages were statistically lower in this group when compared to healthy samples (p < 0.05). Overall, the data indicates that the salivary levels of NO products can be used in combination with other heath indicators to monitor MPS disorders.
ABSTRACT
OBJETIVO: identificar os Diagnósticos de Enfermagem CIPE® relacionados à necessidade humana básica de nutrição na clínica pediátrica. MÉTODO: estudo transversal com abordagem quantitativa, realizado na clínica pediátrica de um hospital público da cidade de João Pessoa, Paraíba. A amostra foi composta por 91 participantes, entre crianças e adolescentes com período de internação superior a 24 horas. RESULTADO: foi possível identificar os diagnósticos: Emagrecimento; Adesão ao Regime Dietético Eficaz; Comportamento Alimentar Infantil, Prejudicado; Apetite, Prejudicado; Obesidade; Amamentação Exclusiva; Amamentação Exclusiva Prejudicada; Problema de Peso Corporal; Sobrepeso; Adesão ao Regime Dietético Prejudicada e Condição Nutricional, Prejudicada. CONCLUSÃO: dentre os diagnósticos, destacaram-se Apetite Eficaz; Comportamento Alimentar Infantil Eficaz; Padrão de Ingestão de Alimentos ou Líquidos Eficaz; Condição Nutricional Positiva e Capacidade para Alimentar-se. A elaboração dos diagnósticos relacionados à nutrição da criança e adolescente corrobora à construção de subconjuntos terminológicos, a fim de garantir a eficácia do cuidado.
OBJECTIVE: to identify the ICNP® Nursing Diagnoses related to the basic human need for nutrition in the pediatric clinic. METHOD: a cross-sectional study with a quantitative approach, carried out in the pediatric clinic of a public hospital in the city of João Pessoa, Paraíba. The sample consisted of 91 participants, including children and adolescents with a hospital stay of more than 24 hours. RESULT: it was possible to identify the following diagnoses: Weight loss; Adherence to the Effective Dietary Regime; Infant Feeding Behavior, Impaired; Appetite, Impaired; Obesity; Exclusive Breastfeeding; Impaired Exclusive Breastfeeding; Body Weight Problem; Overweight; Impaired Adherence to Diet; and Nutritional Condition, Impaired. CONCLUSION: the following stood out among the diagnoses: Effective Appetite; Effective Infant Feeding Behavior; Effective Food or Fluid Intake Pattern; Positive Nutritional Status; and Ability to Feed. Elaboration of the diagnoses related to child and adolescent nutrition corroborates the construction of terminology subsets, in order to ensure care effectiveness.
OBJETIVO: identificar los diagnósticos de enfermería de la CIPE® relacionados con la necesidad humana básica de nutrición en la clínica pediátrica. MÉTODO: estudio transversal con abordaje cuantitativo, realizado en la clínica pediátrica de un hospital público de la ciudad de João Pessoa, Paraíba. La muestra estuvo formada por 91 participantes, niños y adolescentes con una estancia hospitalaria de más de 24 horas. RESULTADO: fue posible identificar los diagnósticos: Pérdida de Peso; Adherencia al Régimen Alimentario Efectiva; Conducta Alimentaria Infantil, Alterada; Apetito Alterado; Obesidad; Lactancia Exclusiva; Lactancia Exclusiva Comprometida; Problema dePeso Corporal; Sobrepeso; Adherencia al Régimen Alimentario Comprometida y Condición Nutricional Deteriorada. CONCLUSIÓN: entre los diagnósticos se destacó Apetito Efectivo; Conducta Alimentaria Infantil Efectiva; Patrón de Ingesta de Alimentos o LíquidosEfectivo; Estado Nutricional Positivo y Capacidad para Alimentarse. La elaboración de diagnósticos relacionados con la nutrición infantil y adolescente coincide con la construcción de subconjuntos terminológicos, a fin de asegurar la efectividad del cuidado.
Subject(s)
Humans , Infant , Child, Preschool , Child , Adolescent , Nursing Diagnosis , Child Nutrition , Infant Nutrition , Adolescent Nutrition , Standardized Nursing Terminology , Hospitals, Pediatric , Nursing Theory , Child Health , Nutritional Status , Cross-Sectional Studies , Adolescent Health , Infant HealthABSTRACT
Yellow fever is an acute viral disease endemic to tropical countries, like Brazil, where, since the 1940s, has no significant documented outbreaks similar to that observed between 2016/2018 (2 045 confirmed cases and 677 deaths; caused by the sylvatic form). The principal manipulating factors inciting this change were absence of appropriate vaccination campaigns and increased urbanization & population growth in forest areas, with prevalence of the virus in the species inhabiting of these areas. The 2016/2018 outbreaks exhibited incidence in areas with historically low or no yellow fever virus activity, triggering a surge in recorded deaths - mainly in the Southeastern states of Brazil. The Brazilian government aggressively responded, reforming the countries' prophylactic measures, including vaccine implementation - as of March, 2018, switching from the former double dose regimen of the vaccine, to a single dose protocol, deemed as adequate. Moreover, some states appropriated the fractionated dosage (1/5 of the standard dose), in foresight of potential vaccine shortages. To prevent the uprising of new sylvatic yellow fever cases in Brazil, it's obligatory the development of effective combative plans, including adaptation of prophylactic measures individually (use of repellents, protective clothing etc.), applicable vaccination campaigns in every endemic region, to raise awareness to locals and visitors alike. Notwithstanding these preventative strategies, the persistence of cases and the recent outbreaks in Brazil, highlight the possible ineffectiveness of combative measures. Based on these considerations, the objective of this review was to raise more awareness of the epidemiological impact of the disease in Brazil.