ABSTRACT
The importance of dermato-neurological examination of intradomiciliary contacts is well known as an important secondary preventive measure in leprosy control, due to the fact that it allows early diagnosis and treatment. This is an intervention trial in an area of high leprosy prevalence (Manaus/Brazil) where the proportion of contacts examined is low. The aim of the study is to assess whether a simple educational session conducted among patients increases contacts examination and leads to early case detection. The intervention group had examined more contacts (p < 0.05) but, paradoxically, presented fewer new cases than the control group. The authors discuss the probable causes for this unexpected outcome, the advantages of the intervention and other related issues.
Subject(s)
Adolescent , Adult , Aged , Child , Child, Preschool , Female , Health Education , Humans , India/epidemiology , Leprosy/epidemiology , Male , Middle Aged , PrevalenceABSTRACT
Pathogenesis of a murine herpes virus was investigated in inbred strains (BALB/c, CBA, AKR and C57BL/10) of mice. After intranasal inhalation, virus was found to replicate primarily in the lungs, followed by haematogenous spread to the target organs (adrenal glands and ganglia). AKR (H-2k) were found to be most susceptible to virus infection while CBA (H-2k) mice appeared to be relatively resistant. Infection of B-cell depleted BALB/c mice resulted in detection of lower lung virus titres in B-cell depleted animals as compared to normal intact mice. Moreover, 3 of 12 normal mice in untreated group died of virus infection while deaths did not occur in the B-cell depleted group. Results of T-cell subset depletion experiments in BALB/c mice revealed maximum mortality in the group depleted of both Lyt-2+ and L3T4+ subpopulations. Infectious virus titres were also higher in lungs of T-cell depleted animals.
Subject(s)
Animals , B-Lymphocytes/immunology , Female , Herpesviridae/pathogenicity , Herpesviridae Infections/immunology , Lymphocyte Depletion , Mice , Mice, Inbred Strains/immunology , T-Lymphocyte Subsets/immunologyABSTRACT
Os A.A. estudam o problema das doencas sexualmente transmitidas no Estado do Para.Fazem inicialmente uma abordagem geral do tema e mostram a gravidade da situacao
Subject(s)
Humans , Sexually Transmitted Diseases , BrazilABSTRACT
Os autores, em analise critica, enfocam as dermatoses mais frequentes, acentuando que as micoses predominam na nosologia amazonica, ultrapassando o grupo dos eczemas, que e o mais prevalente nos Estados Unidos e Europa, bem como no Sul do Brasil. O presente trabalho se baseia em 22.041 prontuarios do servico de dermatologia do professor Domingos Silva - Departamento de Patologia Tropical Centro de Ciencias da Saude - Universidade Federal do Para, no periodo de 1970-1979
Subject(s)
MycosesABSTRACT
Analise critica das dermatoses mais frequentes no Estado do Para. Utilizando o sistema de amostragem, foram trabalhados 5.818 prontuarios do Servico de Dermatologia do Prof.Domingos Silva - Departamento de Patologia Tropical do Centro de Ciencias da Saude UFPa. e referentes aos anos de 1970/1975/1979 Estabelecimento de 20 grupos de dermatoses de maior prevalencia, e analise de alguns aspectos especificos obtidos na pesquisa. Micoses e eczemas constituiram os grupos com maior incidencia. Os dados apresentados embora sujeitos a flutuacao, na dependencia de inumeros fatores e atributos estatisticos, merecem ser aprofundados atraves estudo de maior numero de casos, cobrindo um maior periodo de tempo. Representam, contudo, uma caracterizacao da nosologia Dermatologica na regiao Amazonica