ABSTRACT
Background: Abnormal uterine bleeding is a bleeding from uterine compose that is abnormal in volume, regularity and/or timing that has been present for the majority of the last 6 months. Evaluation of women with abnormal uterine bleeding should comprise history taking, systemic and local examination, laboratory investigations, imaging and different diagnostic procedures including hysteroscopy
Aim of the Work: to assess the accuracy of hysteroscopy in the diagnosis of the cause of bleeding in women with abnormal uterine bleeding
Patients and Methods: This prospective observational study was conducted on 114 patients attended the Early Cancer Detection Unit, Faculty of Medicine, Ain Shams University between July 2017 and April 2018, to assess the role of diagnostic hysteroscopy and histopathology in evaluation of abnormal uterine bleeding
Results: Hysteroscopy had a sensitivity of 91.9%, specificity of 86.5%, positive predictive value of 93.2%, and negative predictive value of 84.2% and diagnostic accuracy of 90.1% for diagnosing the etiology of abnormal uterine bleeding
Conclusion: Hysteroscopy has a definitive role in evaluating patients with abnormal uterine bleeding especially with patient with thick endometrium, in any age group. Hysteroscopy is a safe and reliable procedure in the diagnosis of cases with abnormal uterine bleeding with high sensitivity, specificity, positive predictive value and negative predictive value and the results of hysteroscopy are immediately available. Hysteroscopy and histopathology complement each other in evaluating patients with abnormal uterine bleeding for accurate diagnosis and further treatment
ABSTRACT
Background: labour is a stressful event for the fetus but is well tolerated by most fetuses. However, in some infants stress of labour in terms of metabolic acidosis can lead to Hypoxic Ischemic Encephalopathy [HIE]. HIE around term remains a major cause of neonatal mortality and morbidity with lifelong chronic disabilities. Such insults are not limited to high risk pregnancies but can also occur in about 50% of low risk pregnancies. On current evidence, it is estimated that in about 10 of brain damaged infants, the cause is hypoxia during labour.There has been considerable interest in magnesium sulfate [MgSO4] because magnesium alleviates excitotoxic damage by binding to the magnesium site on the NMDA [N-methyl-Daspartate] glutamate channel
Aim of the Work: magnesium sulphate [MgSo4] for fetal neuroprotection in patients presenting by intrapartum fetal distress at term
Patient and Methods: this is a randomized controlled trial [RCT]. The current study was conducted to single term pregnant women who developed intrapartum fetal distress [as defined later] and need emergency CS [ceaseran section] according to Ain Shams protocol. This study was carried on 200 pregnant females, recruited from observation and labour wards of Ain Shams University Maternity Hospital. The current study was conducted to single term 200pregnant women who developed intrapartum fetal distress and needs emergency CS [cesarean section] according to Ain Shams protocol to examine the effects of administered magnesium sulphate .patient were invited to participate in the study after providing clear explanation of the study and its expected values
Result: patients were invited to participate in this study after providing clear explanation of the study and its expected values. The demographic data of included women showed no significant difference between groups in the age and gestational age There was a significant difference in Apgar score at 5 min between MgSo4 and placebo.MgSo4 had significantly lower the risk of decrease Apgar score < 7 at 5min[p:0.029] .Mgso4 also had significantly lower seizure attacks [p:0.002] and had highly significantly reduce NICU admission rate [MgSo4 group 20[20%] and placebo group 43[43%][p: 0.001]].In MgSo4 group, 23 women reported adverse reactions associated with procedure. Among them, 16 [16%] reported only flushing and 7 [7%] reported only nausea. In placebo group, were 8 [8%] reported flushing and 2 [2%] reported nausea
Conclusion and Recommendation: magnesium sulfate is effective in reducing risk of Apgar score <7 at 5min. Magnesium sulfate appear to be effective in reducing seizure and NICU admission. Magnesium sulphate is associated with maternal morbidity rather than non exposure in the form of nausea and flushing. The improvement in short-term outcomes without significant increase in side effects indicate the need for further trials to determine if there are long-term benefits of magnesium and to confirm its safety