Comparison of Efficacy of Pentoxifyllin with Standard Regimens Dexamethasone and Hyaluronidase in Patients with Oral Submucous Fibrosis

Aims and objectives The purpose of the study was to clinically evaluate the efficacy of oral pentoxifylline 400mg tablets in comparison to intra-lesional injections of dexamethasone (4 mg/ml), hyaluronidase 1, 500 IU and 0.5 ml of lignocaine 2% and a combination of the two in the management of oral sub-mucous fibrosis (OSF) patients. Materials and methods The study population consisted of randomly selected 75 patients with OSF. Patients were divided into three groups. A total of 25 patients were allocated each in dexamethasone group, dexamethasone and pentoxifylline group and pentoxifylline group. Dexamethasone group received weekly intra-lesional injections of dexamethasone (4 mg/ml), hyaluronidase 1, 500 IU and 0.5 ml of lignocaine 2% for a period of 12 weeks. Pentoxifylline group received oral pentoxifylline 400-mg tablets thrice daily for 12 weeks. Dexamethasone and pentoxifylline group received both the drugs. Parameters taken in the study were burning sensation and mouth opening. Results In the present study, improvement in the patients symptomatic parameters were statistically significant (p < 0.001) within groups (intra-group comparison), but not significant (p > 0.001) when compared between the groups (inter-group comparison). Conclusion Study found that the parameters like burning sensation and mouth opening showed statistically significant improvement for all the drug groups. The drug pentoxifylline showed similar improvement in the clinical parameters as that of dexona. For this reason, pentoxifylline can be indicated as a good alternative treatment for OSF in patients in whom dexamethasone is contraindicated, or those who cannot make frequent visits for intra-lesional injections.

Ultrasonographic (USG) Imaging In Orofacial Disease - A Review.

Diagnostic ultrasound has become a radiology subspecialty. Ultrasonography(USG) is a procedure in which highenergy sound waves are bounced off internal tissues or organs and make echoes, which are picked up by the transducer and converted into an electrical signal and then into a real-time black, white and grey visual echo picture, which is displayed on a computer screen. The principles, various indications, advantages, disadvantages and advanced applications of ultrasonography in relation to maxillofacial region are enlightened in this review article.

Oral Lipoma : A Case Report.

Lipoma is the benign tumor of adipose tissue. It constitutes about 1 to 2% of all benign neoplasms of the oral cavity. Intraorally, it occurs predominantly in the buccal mucosa followed by tongue, floor of the mouth, buccal vestibule and rarely in the palate and gingiva. An 80-year-old male reported with a swelling in the right buccal mucosa for the past two years. Clinically the swelling was light yellow in color and had a broad peduncle. The swelling was soft in consistency and mobile. A provisional diagnosis of a lipoma was made. The tumor was excised and confirmed by histopathological examination.

Adenomatoid odontogenic tumour - an unusual extrafollicular variant of the posterior mandible.

Adenomatoid odontogenic tumor (AOT) is a relatively uncommon distinct odontogenic neoplasm. Although this lesion was formerly considered to be the variant of ameloblastoma, its clinical features and biologic behavior indicate, that it is a separate entity. It is a tumor of odontogenic epithelium with duct like structures and with varying degrees of inductive change in the stroma. It is a benign and slow growing tumor which is usually located in the anterior region of the maxilla without pain, and represents 3% of all odontogenic tumors. Most adenomatoid odontogenic tumors (AOTs) occur intra-osseously. They surround the crowns and are attached to the necks of unerrupted teeth in a true follicular relationship, whereas the extrafollicular type has no relation with an impacted tooth, and the peripheral variant is attached to the gingival structures. The aim of this paper is to present a rare case of an extrafollicular AOT occurring in the posterior aspect of the mandible which is distinct

Proliferative verrucous leukoplakia and verrucous carcinoma - A diagnostic dilemma - Case Report.

The definition of leukoplakia is unusual in that it makes the diagnosis dependent not so much on definable appearances as on the exclusion of other entities that appear as oral white plaques. Leukoplakia or tobacco pouch keratosis may be seen on adjacent mucosal surfaces, and verrucous carcinoma is a lesion that may develop from the high risk precancer, proliferative verrucous leukoplakia (PVL). Verrucous carcinoma represents 1 % to 10% of all oral squamous cell carcinomas, depending on the local popularity of spit tobacco use. Many verrucous carcinomas arise from the oral mucosa in people who chronically use chewing tobacco or snuff, typically in the area where the tobacco is habitually placed. Both PVL and verrucous carcinoma may have been reported in the past by the name Oral florid papillomatosis.