ABSTRACT
Introduction: Molluscum contagiosum (MC) is a common skin and mucosal disease caused by MC virus of pox virus family. Lesion manifests both in immunocompromised and immunocompetent individuals. Case Presentation: The case is of MC in 40 year old female patient on right cheek since three months. The growth was asymp- tomatic and nodular. HIV status of the patient was negative with no other medical history. The excised specimen on histological examinations showed lobules of proliferating epithelium. Cells in the center showed basophilic viral inclusion bodies called “Henderson-Paterson bodies” based on these features lesion was diagnosed as MC. Management and prognosis: Lesion was treated surgically. Follow up of six months showed no recurrence or any new lesions. Conclusion: MC is commonly manifested in immunocompromised patients but can rarely be present in immunocompetent patient, so should be considered in the list of differential diagnosis.
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Introduction: Mesenchymal stem cells (MSCs) are the adult stem cells with potential to differentiate into various tissues. Like in other tissues, MSCs also reside in dental pulp after toot development and help in repair and regeneration by differentiating into odontoblasts. Dental Pulp Stem Cells (DPSCs) and Stem cells from Apical Papilla (SCAP) are the type of MSCs from dental papilla and apical papilla respectively. Aim: The aim of this paper is to highlight the characteristics of DPSCs and SCAP. Method: Information was obtained and compiled from published literature and electronic database search engine from PubMed and Google Scholar. Results: In spite of both DPSCs and SCAP having similar cell population origin they possess some different characteristics. Conclusion: The Dental stem cells with different characteristics of similar origin can be utilized in the stem cell based tissue engineering.
ABSTRACT
Cyanobacteria-mediated silver nanoparticles synthesis approach has proven to be more efficient and eco-friendlyin achieving biomedical applications compared to physical and chemical prototypes. In the present work, the silvernanoparticles were successfully synthesized by cell-free extract of freshwater cyanobacteria, i.e., Chroococcus turgidusand Characium typicum. The cyanobacterial silver nanoparticles (CSNPs) were characterized by UV-Vis spectroscopy,scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR)analysis and were further tested for antibacterial and cytotoxic efficiency. The synthesis of CSNPs was confirmed throughvisible color change and shift of peaks at 430–445 nm by the UV-Vis spectroscopy. The size of CSNPs was between22 and 34 nm and oval-shaped which were confirmed by SEM and TEM analyses. The FTIR spectra showed a newpeak at the range of 3,400–3,460 cm−1 compared to control, confirming the reduction of silver nitrate. Furthermore, theantibacterial activity of CSNPs showed highest zone of inhibition with 6.9, 4.0, 2.0, and 3.0 mm against Salmonellaparatyphi, Escherichia coli, Klebsiella pneumonia, and Staphylococus aureus, respectively, whereas in vitro cytotoxicactivity of C. typicum and C. turgidus silver nanoparticles showed remarkable IC50 values with 43.3 and 40.9 ug/mlagainst MCF-7 breast cancer cell line and 20.8 and 55.7 ug/ml against HepG2 cancer cell, simultaneously
ABSTRACT
Background: Diabetes is a chronic metabolic disorder that continues to present a major worldwide health problem, characterized by absolute or relative deficiencies in insulin secretion and/or insulin action associated with chronic hyperglycaemia and disturbances of carbohydrate, lipid, and protein metabolism. It is fast growing disease, gains the status of a potential epidemic in India with prevalence of more than 62 million diabetic individuals currently diagnosed with the diabetes.Methods: The study was conducted at Department of Pharmacology, Kurnool Medical College, Kurnool for a period of 1 year from January 2017 to December 2018. Animals used were albino rats, of Wistar strain, weighing between 150-200gm of either sex. The animals were divided into six groups as: control group (I); pathogenic control group (II) injected intravenously (i.v.) with single dose of STZ (60mg/kg); Morus alba stem bark extract (group-III; 200mg/kg), and group-IV (400mg/kg); group-V animals treated with glibenclamide (5mg/kg, p.o.) following STZ treatment; group-VI, animals treated with bark extract per se (400 mg/kg).Results: The results of this study showed a significant decrease blood glucose level, glycosylated heamoglobin level, and reduction in glutathione and insulin level after STZ administration. These parameters were significantly (p<0.05) reversed by extracts dose dependently.Conclusions: Thus, authors conclude that M. alba stem bark extracts produced significant antidiabetic and antioxidant effect which might be due to the presence of bioactive components such as phenolic and flavonoid content in the extract. The study warrants the need for further evaluated in certain other models of diabetes.