ABSTRACT
OBJECTIVE: To determine the frequency of new onset diabetes mellitus type II in patients of psoriasis attending tertiary care hospital
METHODS: This cross-sectional study done in the out-patient department, Department of Dermatology, Dow University of Health Sciences and Civil Hospital Karachi. Diagnosed cases of psoriasis meeting the inclusion criteria were selected and relevant history taken. Fasting blood sugar levels were checked two times. Informed consent was taken from all the patients. Categorical variables were expressed in frequency and percentage, whereas numerical variables were expressed in mean and standard deviation. Stratification was done with regards to age, gender and duration of psoriasis 1-5 years, to find out the effect of duration upon onset of Diabetes
The data was analyzed using SPSS version 17
RESULTS: Of 114 patients 63 [55.3%] were less than 50 years of age with mean age of 48.8+/-7.3 years and 77 [67.5%] were male with male to female ratio of 2.1:1. Of 114 patients, 68 [59.6%] had duration of psoriasis less than 2 years with mean duration of 3.5+/-2.3 years. Of 114 patients, 9 [7.9%] had blood sugar >126 mg/dl with mean blood sugar 113+/-24.2 mg/dl. Frequency of new onset type II diabetes was 9 [7.9%]. Stratified analysis showed that new onset type II DM is more common in female patients of < 50 years of age
CONCLUSIONS: It is concluded from this study that patients with psoriasis are at the risk of developing type II diabetes and these patients should be screened for diabetes
ABSTRACT
Objectives: the study was carried out to evaluate the prevalence of dermatological problems in patients undergoing haemodialysis and to document the pattern of these skin alterations
Study design: prospective, descriptive
Method: the study comprised of a total number of 300 clinically diagnosed cases of chronic renal failure belonging to either sex being managed by haemodialysis. A detailed dermatological examination of these patients was carried out. The results were recorded on a preformed performa
Results: there were 169 males and 131 females with the age range of 10-80 years. Maximum duration of dialysis was 9 years and minimum 1 month. Xerosis [90.66%] was the most common finding. Pruritus was present in [64.66%]. Hyperpigmentation esp. diffuse [54%], oral lesions [69.3%] including xerostomia and gingival friability, nail changes [61.6%], including pale nails, polished nails and half and half nails and hair changes [56.6%], including dry coarse hair and loss of hair from scalp, arms and legs were also present. Other findings included haemorrhagic diathesis [easy bruisibility, bleeding gums and nasal bleeding], purpuric lesions, excoriation marks, lichenification, AV Shunt complications, cutaneous infections, hypopigmentation, delayed wound healing, hyperpigmented macules on palms and soles, calcinosis cutis, gynaecomastia, solar keratosis and kyrles disease
Conclusion: there is a high prevalence of cutaneous changes in patients undergoing haemodialysis. At least one cutaneous change was found in 96% of patients. Xerosis was the most common finding followed by pruritus, diffuse hyperpigmentation, xerostomia, easy bruisibility, pale nails and half and half nails
ABSTRACT
Langerhan cell histiocytosis [LCH] is a rare disorder that primarily affects children. Its occurrence in adults is very rare. We report a case of 37- year - old male patient who presented with complaints of increased thirst, excessive passage of urine, shortness of breath and skin lesions. The diagnostic workup revealed endocrine involvement with diabetes insipidus, restrictive lung disease, skin biopsy consistent with LCH, bone and periodontal involvement. The skin lesions responded well to Psoralen- Ultraviolet Radiation A therapy[PUVA]. He showed general improvement on systemic chemotherapy