ABSTRACT
Background: chronic hepatitis C virus [HCV] infection has been reported in association with several extrahepatic manifestations. Chronic HCV infection is also associated with both direct and indirect effects on pulmonary tissue
Purpose: to evaluate phenotypes of respiratory manifestations of chronic hepatitis C virus
Patients and Methods: 1-this study was conducted on 150 Egyptian patients with chronic hepatitis C. Patients were selected from those attending the in patients and out patients clinic of the Tropical Medicine and Chest Departments, Al-Azhar University Hospital-Damietta from September 2016 to Septamber 2018. 2-also ,50 healthy subjects matched for age and sex were included as volunteer.3-consent was informed by all patients and volunteer shared in this study
Results: C.O.P.D: documented in 32 patients [21.3%].Asthma: documented in 15 patients [10%] of all patients. Air way hyperreactivity: documented in 15patients [10%] of all patients. Idiopathic pulmonary fibrosis [IPF]: is presented in 37 patients [24.6%]. Pneumonia: documented in 10 patients [6%] of all patients. Transudative pleural effusion: documented in 10 patients [6%] of all patients. Adenocarcinoma: documented in 5 patients [3.3%] of all patients. Pseudolymphoma: documented in 1 patient [0.006%] of all patients. Lung abscess: documented in 10 patient [6%] of all patients. Pulmonary embolism: documented in 5 patients [3.3%] of all patients. Hepatopulmonary syndrome: documented in 10 patients [6%] of all patients
Conclusion: Chronic hepatitis C virus infection is related to the development of several pulmonary abnormalities. These pulmonary manifestations of HCV infection are frequently underdiagnosed
Recommendations: Any patient with chronic HCV infection should be evaluated with HRCT chest and pulmonary function tests for early diagnosis of pulmonary abnormalities to prevent further complications
ABSTRACT
HRCT scanning increasingly used in bronchial asthma. This work was planned to assess the thickness of airway wall in chronic bronchial asthma by using HRCT scanning and its relation to pulmonary function and asthma severity. The study was carried out on 25 chronic asthmatic patients 14 females and 11 males and 10 normal healthy subjects as a control group they were matching as regard age, gender, and height All cases were subjected to the following: complete history taking complete clinical examination, plain chest radiography, pulmonary function tests and HRCT chest scanning at 5 levels; top of aortic arch, at the main carina, 1 cm below main carina, at the level of pulmonary veins, and 2 cm above right hemidiaphragm. Asthmatic patients were classified into severe asthma II cases, moderate asthma 10 cases, and 4 cases as mild asthma, the following data were found: There were no statistically significant difference between cases and control groups -in age, sex or height. There were highly significant increases in FVC, FEV[1], and FEF25-75% and low significance increase in FEV[1]/FVC among cases after use of bronchodilator than before it There was no significant difference in pulmonary function before and after BD among control group There were significant difference between cases and control groups in all pulmonary function results. There were high significant difference between cases and control groups in FEV[1], FVC, FEF 25-75% after use of bronchodilator. There were statistically significant negative association between wall thickness and FEV[1]/FVC and FEF25 75%. There were statistically negative significant correlation between wall area and FEF25-75%, and FEV[1]/FVC- There were significant negative correlation between [thickness/diameter] T/D ratio and FEF 25-75% and FEV[1]/FVC. There were significant correlation between airway wall area and severity of bronchial asthma. No significant correlation between airway wall thickness and FEV[1] but there is negative association between wall thickness and FEF25-75% and FEV[1]/FVC ratio. This study showed strong positive correlation between wall thickness, wall area and asthma severity and duration of asthma There were significant correlation between asthma severity, duration, and thickness of the airway wall and wall area%. Many changes as bronchiectasis, mucoid impaction, emphysema and bronchial dilatation were found in chronic asthmatics