ABSTRACT
The capacity of stem cells of peritonium of mesodermal origin to undergo metaplastic transformation and form different tissues developed from mesoderm germ layer is exploited with ulterior motive to use it in the management of human diseases. The excised fallopian tube was replaced with a tube on a stent constructed from autogenous peritoneum from a suitable donor site. The effect of the surroundings environment of the new tissue system to which the peritoneum stem cells are now exposed was studied for 3, 6 and 12 months period in live animal models. The gross and histological studies revealed development of all the component of the wall of the fallopian tube. The lumen of the constructed peritoneal tube was well preserved in its whole length including the anastomotic sites. The scientific rationale of the working hypothesis on which the work is based, is discussed.
Subject(s)
Anastomosis, Surgical , Animals , Dogs , Fallopian Tubes/cytology , Female , Humans , Mesoderm/cytology , Metaplasia , Peritoneum/cytology , Regeneration/physiology , Stem Cell Transplantation , Stem Cells/cytology , Transplantation, AutologousABSTRACT
Regeneration of ureter in vivo is possible from peritoneal stem cells as both are derivative of embryonal germ layer mesoderm. The peritoneal stem cells are engaged in repair of loss due to normal wear and tear by differentiation and proliferation. With pluripotent nature, they have a capacity to undergo metaplastic transformation to various mesodermal tissues. The intrinsic cell factor along with regional tissue organisers coupled with functional need of the region, a desired metaplastic transformation to ureteric wall components is possible.