Effects of nonylphenol exposure via placenta on early nervous reflex and locomotives of offspring in rat / 中华劳动卫生职业病杂志

<p><b>OBJECTIVE</b>To explore the influence of nonylphenol (NP) on the neural behavioral development of filial generation rats exposed via placenta.</p><p><b>METHODS</b>On the first day of the pregnancy, the SD rats were divided into four groups, and orally administered with NP at doses of 0, 50, 100 and 200 mg/kg on gestational day 9 approximately 15 respectively. The offspring rats of each groups were examined to observe the impact of NP on the early physiological, neurobehavioral development. The changes of filial generation body weight (from generation day 1 to 28) were measured. Brain tissues were stained with Hematoxylin-eosin and Congo red to observe with optical microscope.</p><p><b>RESULTS</b>In contrast to the control group, the early physiological markers (pinna detachment, hair growth, tooth growth and eye opening) and the early neurobehavioral development indices (surface righting, air righting, acoustic startle and visual placing) were significantly delayed in the groups of NP 200mg/kg dose (P < 0.05). The developing time of physiological markers decreased from (4.5 +/- 0.8, 5.2 +/- 0.8, 12.7 +/- 1.4, 16.0 +/- 1.7) d to (3.6 +/- 0.5, 3.6 +/- 0.5, 11.1 +/- 1.1, 12.7 +/- 1.3) d while neurobehavioral developing time decreased from (6.5 +/- 0.8, 11.3 +/- 0.5, 11.2 +/- 1.0, 20.2 +/- 1.0) d to (5.1 +/- 0.4, 8.3 +/- 0.5, 9.3 +/- 0.5, 9.3 +/- 0.5) d (P < 0.05 or P < 0.01). The body weights of filial generation rats were decreased obviously from 1 st day to 28th day. Histopathological examination displayed that hippocampal neurons had congestion and oedema in the group of 100, 200 mg/kg dose.</p><p><b>CONCLUSION</b>Exposures to NP during gestation might impair the neurobehavioral development of F1 rats significantly.</p>

Clinical observation on treatment of cerebral infarction by combined therapy of acupuncture with extremities tissue separating manipulation / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To observe the curative effect of combined treatment of extremities tissue separating manipulation (ETSM) and acupuncture on cerebral infarction (CI).</p><p><b>METHODS</b>CI patients were randomly divided into 3 groups. Group A was treated with drug-therapy only, Group B was treated with drug-therapy plus acupuncture and Group C was treated with drug-therapy plus ETSM and acupuncture. All patients were treated for 15 successive days for evaluating curative effect.</p><p><b>RESULTS</b>The cured-markedly effective rate, total effective rate and nerve function deficit score after treatment was 28.6% , 71.4% and 17.57 +/- 1.51 scores in Group A, 48.4%, 80.6% and 13.97 +/- 1.38 scores in Group B, and 81.3%, 93.7% and 11.00 +/- 1.51 scores in Group C, respectively. Significant difference was shown in comparison of Group A with Group B, also in comparison of Group C with Group A and B (All P <0.05).</p><p><b>CONCLUSION</b>ETSM combined acupuncture has a good therapeutic effect on CI.</p>