ABSTRACT
OBJECTIVE@#To study the changes and significance of prethrombotic state indexes in patients with malignant cancer.@*METHODS@#The expression of CD62p on platelets, level of plasma tissue plasminogen activator (t-PA), level of serum endothelin (ET-1), activated partial thromboplastin time (APTT), fibrinogen ( FIB), prothrombin time (PT), and thrombin time (TT) were examined by flow cytometer, enzyme-linked immunosorbent assay, radioimmunoassay method, and auto coagulometer.@*RESULTS@#The average expression of CD62P, level of plasma FIB and serum ET-1 in the tumor group increased compared with those in the control group (P0.05).@*CONCLUSION@#The platelet is activated, the thrombin activity increases, and the fibrinolytic function declines in patients with malignant cancer; there is an obvious prethrombotic state in patients with malignant cancer.