ABSTRACT
SUMMARY OBJECTIVES: This study examined the association between handgrip strength and body composition, physical fitness, and biomarkers in postmenopausal women with metabolic syndrome. METHODS: A total of 75 postmenopausal women were diagnosed with metabolic syndrome participated in this study. Muscle strength was assessed via a hydraulic grip strength dynamometer; physical fitness tests included a timed-up-and-go, arm curl test, and 30-s chair stand. Body composition was assessed via bioelectrical impedance, from which estimates of fat mass, body fat percentage, fat-free mass, and visceral fat area were determined. Fasting plasma glucose and glycated hemoglobin were measured via blood sample analyses. Multiple linear regression analyses were conducted using handgrip strength as the dependent variable and using body composition, physical fitness, and biomarkers as independent variables. RESULTS: The results revealed that 52% of the total sample were classified as obese, 37.3% as overweight, and only 10.7% as normal weight. Significant correlations were present between handgrip strength and fat-free mass (p=0.002; R=0.590), mean blood pressure (p=0.002; R=0.450), and arm curl (p=0.001; R=0.795). CONCLUSION: This study showed that handgrip strength was predictive of fat-free mass, blood pressure, and upper limb strength performance.
ABSTRACT
O lúpus eritematoso sistêmico (LES) é uma doença sistêmica, de etiologia desconhecida e multifatorial. Está associado a diversas manifestações cardiovasculares como aterosclerose acelerada, pericardite, miocardite, valvulopatias, endocardite de Libman-Sacks, entre outras, contribuindo para a morbidade e mortalidade dos pacientes. Conclui-se, então, que tal colagenose deverá ser lembrada como causa de cardiomiopatia.
Systemic lupus erythematosus (SLE) is a multifactorial systemic disease of unknown etiology. It is associated with several cardiovascular manifestations, such as accelerated atherosclerosis, pericarditis, myocarditis, valvulopathies and Libman-Sacks endocarditis, amongothers, contributing to patient morbidity and mortality. It thus follows that this collagenosis should be recalled as a cause of cardiomyopathy.
Subject(s)
Humans , Male , Adult , Heart Failure/complications , Lupus Erythematosus, Systemic/etiology , Myocarditis/complications , Myocarditis/diagnosis , Cardiomyopathies/mortality , Echocardiography/methods , EchocardiographyABSTRACT
Septo-optic dysplasia (SOD), also referred to as de Morsier syndrome, is a rare congenital condition, characterized by two of the classic triad features: midline brain abnormalities, optic nerve hypoplasia (ONH) and pituitary endocrine dysfunction. We report 5 children with SOD, originally referred to be evaluated due to short stature, who also presented bilateral optic nerve hypoplasia, nystagmus and development delay. In 4 of the patients, we identified neuroimaging abnormalities of the hypothalamo-pituitary axis such as anterior pituitary hypoplasia (3/5), ectopic posterior pituitary (4/5), thin or absent stalk (3/5) and empty sella (1/5). We also encountered diverse pituitary deficiencies: growth hormone (3/5), adrenocorticotropic hormone (3/5), thyroid-stimulating hormone (2/5) and antidiuretic hormone (1/5). Only one child presented intact pituitary function and anatomy. Although rare, SOD is an important cause of congenital hypopituitarism and it should be considered in children with optic nerve hypoplasia or midline brain abnormalities for early diagnosis and treatment.
A displasia septo-óptica (DSO, síndrome de Morsier) é uma condição congênita rara definida por dois critérios da tríade: defeitos de linha média, hipoplasia de nervo óptico e insuficiência hipotálamo-hipofisária. Descrevemos 5 casos de DSO, encaminhados por baixa estatura, com hipoplasia dos nervos ópticos, nistagmo e atraso global do desenvolvimento. Destes, 4 possuem alteração na ressonância magnética de sela túrcica e insuficiência hipotálamo-hipofisária, tendo sido observada adeno-hipófise hipoplásica (3/5), neuro-hipófise ectópica (4/5), haste afilada/ausente (3/5) e sela vazia (1/5), além de déficit dos eixos somatotrófico (3/5), adrenocorticotrófico (3/5), tireotrófico (2/5) e do hormônio antidiurético (1/5). Apenas um paciente não apresenta alteração anatômica ou funcional do eixo hipotálamo-hipofisário. Embora rara, a DSO é causa importante de hipopituitarismo congênito, devendo ser considerada em crianças com hipoplasia de nervo óptico ou defeito de linha média para seu diagnóstico e tratamento precoces, evitando seqüelas graves.
Subject(s)
Adolescent , Child , Child, Preschool , Female , Humans , Male , Hypopituitarism/diagnosis , Hypothalamo-Hypophyseal System/pathology , Sella Turcica/abnormalities , Septo-Optic Dysplasia/diagnosis , Hypopituitarism/etiology , Magnetic Resonance Imaging , Septo-Optic Dysplasia/complicationsABSTRACT
O emprego do TSH exógeno com o objetivo de aumentar a captação de iodo radioativo, por metástases de carcinoma tireoideano bem diferenciado, já ultrapassa cinco décadas. Durante este período, observamos a evolução na obtenção deste TSH. O primeiro TSH foi de origem bovina, seguido pelo de origem hipofisária de cadáveres e, finalmente, o mais recente foi obtido por tecnologia de DNA recombinante, intitulado TSH recombinante humano (rhTSH). Trata-se de uma ferramenta auxiliar no tratamento do carcinoma de tireóide, com resultados comprovados no aumento dos níveis séricos de TSH, proporcionando o aumento da captação de radioiodo por remanescentes tireoideanos e estimulação na liberação de tireoglobulina. Apesar de sua indicação para uso ser restrita à neoplasia tireoideana, podemos observar seu emprego no tratamento de bócios multinodulares de tireóide. O presente artigo destina-se a uma breve revisão do uso do rhTSH nos dias atuais