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ABSTRACT This work aimed to determine whether seropositivity to Helicobacter pylori infection was an independent risk factor for hyperhomocysteinemia patients with cardiovascular disease. The H. pylori IgG, IgA and homocystein levels in 96 patients with cardiovascular disease and 64 participants free of cardiovascular disease as control subjects were determined by ELISA assay. The results showed that seropositivity to H. pylori IgG and IgA levels of coronary artery disease (CAD)patients was significantly higher than the controls and CAD patients with H. pylori IgG and IgA negative antibodies. A significant correlation was found between the seropositivity to H. pylori IgG and homocysteine levels of CAD patients in comparison with the controls and CAD patients with seronegativity to H. pylori IgG and IgA (r=0.233, P= 0.019 ). The involvement of H. pylori infection in atherosclerosis process was based on the chronic inflammation, which might facilitate the CAD-related pathologies. The effect of the presence of H. pylori infection on homocysteine levels elevation in the CAD patients (as a risk factor independent of other traditional factors) was remarkable.
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Background and Objectives: leptin plays an important role in the regulation of energy homeostasis and the beginning of the maturation process. The effects of exercise trainings on leptin levels are unknown. The purpose of this study was to compare leptin levels, body composition and aerobic power in girl athletes and non-athletes in the early and late puberty
Materials and Methods: eighteen girls in the early puberty with a mean age of 10.25+/- 0.39 years and 18 girls in the late puberty with a mean age of 14.72+/- 0.42 years [in each group, n=9 Taekwondo athletes and 9 non-athletes] voluntarily participated in this study. Evaluation of puberty stage was based on the 5-stage Tanner model. Blood leptin was measured by ELISA. After determining body composition using a caliper, maximum oxygen consumption was measured using the Queen College step test
Results: in the late pubertal, girl athletes had higher leptin levels than non-athletes [p<0.05]. Girl athletes than non-athletes had a higher level of aerobic power [p<0.05]. Plasma leptin concentrations correlated directly with body fat percentage, BMI, fat mass and inversely related to aerobic power [p<0.05]
Conclusion: we encountered decrease in serum leptin following a regular exercise in girl athletes at the late puberty, at the early puberty; this decrease was not significant. However, the benefits of regular physical activity in girl athletes to increase aerobic power were evident at the early and late puberty
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This study aimed to establish a comprehensive screening and referral system for chronic non-communicable diseases [CNCD] in the routine primary health care, and to determine the prevalence of diabetes, pre-diabetes, metabolic syndrome, and dyslipidemia in adult population invited by public announcement to the Health clinics in Isfahan, Iran. This survey was conducted from March 2010, and the current paper presents data obtained until November 2011. To provide health services for prevention and control of CNCDs, with priority of type2 diabetes mellitus, Health clinics were established in different parts of Isfahan city with a population of approximately 2,100,000 in Iran. The general populations aged 30 years and above were invited to the Health clinics by public announcement. A total of 198972 participants were screened. The mean age of participants was 47.8 years [48.5 men, 47.3 women], with a range of 1 to 95 years old and standard deviation of 12.3 years [12.7 men, 12.1 women]. Overall, 22% of participants had impaired fasting glucose, 25% had hypercholesterolemia, 31% had hypertriglyceridemia, and 20% had metabolic syndrome. The high prevalence of dysglycemia and diabetes in our survey may serve as confirmatory evidence about the importance of mass screening and early diagnosis of CNCDs' risk factors. Our model of establishing Health clinics, as a comprehensive referral system in the routine primary health care can be adopted by Middle Eastern countries, where CNCDs notably diabetes are an emerging health problem