Knowledge assessment of neonatal care among postnatal mothers

99% of 4million neonatal mortality occur in developing countries every year. Mortality rate of newborns accounts for 18.3 per 1000 live birth that comprised 69% of IMR and 56% of Under 5 mortality in IRAN. A Comparison of statistical trend between infant and newborn rate from 1988 to 2001 revealed a considerable decrease in IMR but slightly decrease in NMR. training postnatal mothers and Preventing neonatal mortality rate is effective .This study has been carried out for assessing the Knowledge regarding to neonatal care among postnatal mothers. In this cross-sectional study, from target population of mothers of referral neonates into Ravar/Kerman medical health center. A sample was chosen with convenient sampling method .Then a questionnaire consisting of questions regarding to assessing generalized surveillance during neonatal and Icter period and Umbilical cord surveillance were collected. Data were analyzed using SPSS 19. T test and ANOVA were used for analyzing the relationship. 316 mothers with mean age of 25.87 were studied. 8.2% of mothers had poor knowledge, 78.5% moderate and 13.3% had good knowledge. Also urbanmothers less than 24 year of age with 2 or 3 children and higher level of education obtained significantly higher knowledge score. The results showed that Knowledge levels of 78.5% of mothers were moderate. So it is imperative to provide comprehensive training in the field of newborn and infant care for mothers

effect of clofibrate on decreasing serum bilirubin in healthy term neonates under home phototherapy

This study was designed to determine the effect of clofibrate on neonatal uncomplicated jaundice treated with home phototherapy. This clinical trial study was performed on 60 newborns with jaundice that received home phototherapy. Inclusion criteria were body weight between 2500 to 4000 gr, breastfed, I total serum bilirubin [TSB] between 14 to 20 mg/dl, aged over 72 hours. The neonates were randomly divided into two groups. All received home phototherapy. Group I received a single dose of 50 mg/kg clofibrate and the other group served as control group. Total serum bilirubin level was measured every 24 hours. Two groups were matched regarding weight, sex, age and first TSB. At 24 and 48 hours of treatment, the mean values of TSB in the clofibrate group were 13.72 [1.56], 9.5 [0.56] and in the control group 15.30 [1.44], 12.6 [1.44]. The results show that TSB was significantly decreased after 24 and 48 hours in clofibrate group [P<0.001]. The mean duration of phototherapy in group I was 72[0.0] hours and in the control group 76.80 [ +/- 9.76] hours. The duration of phototherapy was significantly shorter in clofibrate group [P<0.001]. Clofibrate is effective for outpatients with neonatal hyperbilirubinemia who are under home phototherapy. Of course, further studies are needed for approved routine use of this drug in the treatment of neonatal jaundice

effect of clofibrate on neonatal hyperbilirubinemia in uncomplicated jaundice

Clofibrate has been used for several years as a hypolipidemic drug. Our aim was to study the effect of Clofibrate on neonatal hyperbilirubinemia in uncomplicated jaundice. This clinical trial study has been conducted on 90 normal term neonates who were admitted for uncomplicated jaundice in 17th-Shahrivar Children's Hospital of Guilan University of Medical Sciences from September 2005 to January 2006. The data included: age, sex, total and direct serum bilirubin, weight and duration of hospitalization. All data were analyzed by using statistical methods. All 90 infants enrolled in our study had received phototherapy. The infants were divided into Clofibrate group [G1] consisting of 26 boys [57.8%] and 19 girls [42.2%] and Control group with 24 boys [53.3%] and 21 girls [46.7%] [G2]. There were no statistically overt differences between the two groups regarding sex distribution, age, weight and total serum bilirubin level at admission. Mean values for total bilirubin of serum in Clofibrate group 12, 24, 36, and 48 hours after admission were significantly lower than those for Control group [P<0.00l]. The mean time needed for phototherapy in Clofibrate group [38.8] [20-48h] was significantly shorter than that in control group [68.7] [36-96h] [P<0.00l]. Clofibrate is effective and probably a safe drug for neonatal hyperbilirubinemia that can decrease the time needed for phototherapy and hospitalization, although further studies with a more precise and longer follow up is needed for proving its safety to be used routinely in the treatment of neonatal hyperbilirubinemia