[Role of cytokines in patients with arthritis and low back pain brucellosis]

Cytokines are secreted as the molecular products of different cells in particular T-Lymphocyte which contribute in the processes of immune responses. Therefore, the study may provide valuable information regarding the function of cell-mediated immunity [CMI] in this disease. This study was performed in the medical centers of Mashhad University of Medical Science. 40 Patients with brucellosis and 40 normal samples took part in this investigation. Diagnosis of the disease was based on case history clinical examination and serological tests. The levels of TNF-alpha, IL-2, IFN-gamma, IL-4, and IL-10 in serum were measured using ELISA method. The levels of the random variables IL-2 and IL-10 were tested by Kolmogrov Smirnov test and shown to be normal [p<0.05]. Other cytokines including IL-4, IFN-gamma, and TNF-alpha of patients serum were not normal. The results indicated that the levels of IL-10 in the sera of patients had increased [p<0.001]. IFN-gamma level showed it has increased in patients [p<0.05]. The level of IL-2 and IL-4 and TNF-alpha in the sera of patients did not show any appreciable difference with those of normal controls [p>0.1]. Kruskal-Wallis test showed a significant difference in IFN-gamma in the two groups. Our results would suggest a definite role of IFN-gamma, and IL-10 in sera of patients with arthritis and low bake pain brucellosis

[Case presentation of a patient with hyper immunoglobulin E syndrome]

IgE syndrome, also known as Job's syndrome, is a very rare cause of immunodeficiency. It is presented with recurrent staphylococcal abscesses in the skin, lungs, and other organs as well as itching dermatitis since the early stages of life. Significant increase serum level of IgE, eosinophilia, and normal serum levels of other immunoglobulines are the major features of this abnormality. Our patient was a 12 month old girl with presenting symptoms of itching dermatitis and recurrent skin and lung infections. She also had the history of umbilical chord infection as well as several attacks of dysentery. On physical examination she was pale and had a coarse face. She also had symptoms of mild malnutrition and several erythematous papules covered her body. Serum level of IgE was more than 150 IU/ml, while serum levels of the other immunoglobulines and complement were within normal limits. These findings established the diagnosis of hyper IgE syndrome for the patient. Combination of itching dermatitis, recurrent skin and lung infections, and nail dystrophy as well as significant increase in serum IgE level, suggests hyper IgE syndrome as the most likely diagnosis