Plasma concentrations of atrial natriuretic peptide in dehydrated patients

The levels of the plasma atrial natriuretic peptide[ANP] are affected by the plasma volume reduction. In the present work, the levels of ANP were measured in 32 infants and children suffering of mild, moderate and severe dehydration caused by gastroenteritis of various etiology. The results indicated that the levels of ANP are decreased according to the degree of dehydration in comparison to the well rehydrated subjects. These results suggest that ANP might play a role in the pathophysiology of dehydration

Plasma atrial natriuretic peptide in thyroid dysfunction.

The vascular and renal changes due to the effect of atrial natriuretic peptide [ANP] that have been discovered are similar to the well known actions of thyroid hormone. Therefore we have investigated the possible involvement of thyroxine[T[4]] and triiodothyronine[T[3]] on the release of ANP. Plasma ANP in euthyroid subject was 40.8 +/- 9.3 pg/ml, which was lower than ANP level in hyperthyroid subjects [66.3 +/- 27.1 pg/ml], [p <0.001] and higher than ANP level in hypothyroid subjects [27.5 +/- 11.6 pg/ml] [p < 0.001]. Furthermore, the plasma ANP level were significantly positively correlated with circulating levels of [T[3]] and [T[4]]. These results could suggest the involvement of ANP in the renal manifestation of hyper and hypothyroidism